The results of enter sorbent — dioctahedral Smectite (Neosmektin) — usage as part of complex therapy of children with atopic dermatitis (ATD). It is shown that the administration of Smectite favored better efficacy of baseline treatment of ATD, more express and quick regression of skin manifestations of the disease, decrease in number of children with eosinophilia. High efficacy of ATD treatment with Smectite indicates the pathogenetic justification of efferent therapy of the disease. Observation results witness the good tolerability of Smectite: side effects related to the treatment were only observed in 14 percent of children.Key words: children, atopic dermatits, smectite, treatment.