This Virtual Issue of International Journal of Social Research Methodology is about the use of software to assist qualitative data analysis, a topic that has been a popular focus since the Journal’s beginning back in 1998. Some articles republished here reflect upon the ‘big issues’ raised by the use of specialist software to support analytical processes that until two decades ago could only be carried out by hand. Key issues include how the computer capabilities extend the analysis possibilities, are used in different research traditions, and enhance or impair researcher reflexivity. Other issues comprise the teaching and learning of qualitative methods, and the controversies and claims around using software to support the generation of knowledge. The collection is intended to stimulate further debate on the use of software in disciplines where it is already established and to open up the discussion in traditions where it is not.