Introduction. Situations of interdisciplinarity in science in the last third of the 20th century are associated with going beyond disciplinarylines and the boundaries of laboratories. At the beginning of the 21st century, transdisciplinarity began to be considered as a bridgebetween the growth of scientific knowledge and the solution of specific problems in the practical sphere. The boundaries between scientificdisciplines are becoming flexible and researchers are faced with questions of combining truth and practical utility. The aim and task of theresearch are to reveal the post-nonclassical perspective of the transdisciplinarity strategy of science. Research methodology. Themethodological basis of the research is an interdisciplinarity approach and a transdisciplinary strategy of the philosophy of science, withinwhich modern practices of science and art are analyzed as a form of cultural hybridization. Research results. Focusing on the analysis ofcurrent practices of science and art from the standpoint of the philosophy of science, the study represents a turn to a transdisciplinarystrategy of updating the communicative and methodological experience of science. Communicative attempts to overcome disciplinarydifferences show the difficulties of solving the problem of combining truth and practical utility. The concept of a "tradingzone" is used toexplain the possibilities of overcoming inconsistencies and establishing communication. Discussion. A special feature of Science Art is anew understanding of art and science associated with difficulties in the modern distinction between scientific research and an artistic project.The term "scientific art"indicates the original actual aesthetics and artistic practices and their inclusion as elements in the scientific process.Science Art is considered a transdisciplinary platform for the implementation of experimental projects arising from the consideration ofcomplex phenomena in the process of becoming at the limits of the competencies of natural-social-humanitarian knowledge. Conclusions.Transdisciplinarity is considered a meta-level, which is based on a combination of various cognitive strategies and ways of thinking, acombination of theory and practice. The relevance of the methodology is strengthened by the tendency of coherence of socio-humanitarianand natural-scientific strategies. Science Art as a phenomenon of contemporary synthesis is such a new field of research at the intersectionof science and art, where innovations arise. У статті досліджується проблема оновлення комунікативно-методологічного інструментарію філософіїнауки та можливостей застосування міждисциплінарних підходів і трансдисциплінарних стратегій. Трансдисциплінарністьрозглядається як метарівень, який ґрунтується на поєднанні різноманітних когнітивних стратегій та способів мислення,поєднанні теорії і практики, істинності та практичної корисності. Окреслюються перспективи наукового мистецтва яктрансдисциплінарної платформи для втілення спільних експериментальних проектів науки і мистецтва.