Over the last ten years Molecularly Imprinted Polymers (MIPs) have become an important research target as well as an instrument for solving industrial needs in separation and sensing. The work, however, is hindered by the poor processability of bulk MIP materials which cannot be easily integrated with sensors and assays and the polyclonal nature of the binding sites in materials synthesised using traditional approaches. These problems will be solved by developing solid-phase photoreactor which combines nanoparticle synthesis with affinity separation; the product of this process is comparable to natural monoclonal antibodies. The envisaged protocol includes synthesis of imprinted nanoparticles on solid supports with immobilised target molecule (template) which will double as affinity support for selection of high-affinity particles. This unique process has the added advantage of easy automation/scale-up. Currently there is no device available on the market for the production of MIP nanoparticles in the quality and quantities required by industry. Our main goal is to produce a working prototype synthesiser for industrial application based on the process described above and optimise its operational parameters for demonstration of its functional properties and market potential.