This project aims to explore Islamic and Confucian perspectives on ethical issues pertaining to human genome editing namely safety and efficacy of the technology, human dignity and rights, modifying God’s creation, and human genetic enhancement. It will identify the similarities and differences between both perspectives and highlight the common ethical principles that could be applied in assessing the permissibility of human genome editing technology. This project is a qualitative study that involve normative literature analysis and comparative analysis between Islamic and Confucian perspectives. Given that Islam and Confucianism are among the main ethical traditions in the world, findings from this project would help stakeholders in understanding both perspectives and formulating policies and guidelines regarding responsible research and use of human genome editing. It is hoped that it would encourage more cross-cultural studies that contribute to the global discussion on ethics of human genome editing.