I work on cell competition, a process where relatively less fit cells (losers) are eliminated by relatively fitter neighbouring cells (winners). There are many types of cell competition and in my PhD I will focus on Minute cell competition. In Minute cell competition cells that have lost one copy of a ribosome gene (called Minute) are induced to die by wild-type cells. Minute cell competition acts as a quality control to maintain tissues healthy and is likely to contribute to the elimination of cells with tumorigenic potential. We are interested in understanding how proximity with winner cells modifies the cellular state of Minute cells so that they behave as losers and die. Our approach involves introducing groups of wild-type-cells in a Minute background in developing fly epithelia. In my work I will characterise how cell competition changes specific cellular processes such as translation, autophagy and oxidative stress. I will also look at gene expression changes induced during cell competition in loser Minute cells, to identify novel additional factors affected by winners and involved in cell competition. This work is likely to identify new components that, by modulating cell competition, could be important in maintaining tissue health and in cancer prevention.