Malaria parasites can get stuck in the placenta in pregnant women leading to an increased likelihood of death and illness in the mother and child. There are a group of cells present in the body called regulatory T cells (Treg) that can dampen down immune responses and inflammation when an infection occurs. The role of these cells in infection and inflammation is poorly understood. The overall aim of this study is to understand the role that Treg cells play in the immune response to placental malaria infection. In this study we will use special techniques to look for Treg cells in woman with and without malaria infection of the placenta. This will allow us to establish whether Tregs accumulate in the placenta during malaria infection compared to uninfected placentas. This is important since it will help us to understand how the immune response is regulated during placental malaria infection. It is also important because it is difficult to get tissue samples from humans and hence most immune studies in humans are carried out using blood samples. This study will tell us whether what we observe in the placental tissue mirrors the results from blood samples. If we can understand exactly what placental malaria infection does to the mothers and babies this may offer new ways to treat them and prevent the complications.