Integrating genome structure and function
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Each human cell contains 2m of DNA, yet our genome has to function within the context of the cell nucleus that is only 10 thousandths of a mm in diameter. This remarkable feat of packing is achieved by folding the DNA sequence up with proteins, to form a structure called chromatin. We now realise that chromatin not only allows the DNA to fit inside of the cell, but that it also controls the way that the DNA is read. Using a combination of biochemistry and microscopy, we are investigating what different chromatin structures there are in mammals, and how they are normally regulated and changed during development to allow different sets of genes to be switched on and off. Once we understand the chromatin architecture of the normal genome, this will allow us to understand how altered chromatin structure can contribute to disease.
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