This broad programme of research is carried out by applying computational and mathematical technology for both the development and application of algorithms and analysis of molecular biology data. Often this data is large-scale, for example including the genome sequences of thousands of people or thousands of different organisms. Other examples of data types include the 3D structure of proteins, networks of interactions between proteins, gene expression, etc. By taking datasets produced by many experiments, using computers we are able to: answer fundamental questions such as how evolution takes place at the molecular level, and what are the genetic determinants of human phenotypes; answer questions of practical importance such as how to reprogram one human cell type into another for regenerative medicine; and to invent computational tools and techniques that enable others to answer questions of fundamental and practical importance in biology.