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Diffusion-weighted MRI using an endovaginal coil for evaluating early cervical cancer

Funder: UK Research and InnovationProject code: G0802470
Funded under: MRC Funder Contribution: 162,552 GBP

Diffusion-weighted MRI using an endovaginal coil for evaluating early cervical cancer

Description

Magnetic resonance imaging is currently the gold standard for assessing the neck of the womb and surrounding tissues in cases of cervical or suspected cervical cancer. However, conventional techniques lack both resolution (pixel size 0.6 mm) and contrast when standard MRI pulse sequences are used. It is possible to increase the resolution of the images by placing a receiver probe close to the part under study to maximise signal and reduce noise from that region. We have previously developed an endovaginal receiver for use at 1.5T and shown significant improvement in resolution. However contrast between tumour and non-tumour tissue remains low and requires use of specialist sequences such as diffusion-weighted images which are inherently low on signal-to-noise ratio. Production of an endovaginal coil for use at a higher field strength (3.0T) would enable use of higher resolution diffusion-weighted imaging. We propose therefore to build an endovaginal device for use at 3.0T, optimize the diffusion-weighted imaging and compare the accuracy of conventional MRI techniques with and without the addition of diffusion-weighted imaging for detecting early stage cervical cancer by comparing with the tissue findings at surgery.

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