The adventure of Industry 4.0 is already assuming its rhythm and requires proactive adaptation by businesses/industries, HEIs and governments. One main concern relays on occupations transformation towards a digital culture, where some occupations are threatened by redundancy, others are growing rapidly, and a 3rd set of new occupations will emerge.Through a true community of practice, the Universities of the Future project will address the existing gap at higher education offer by developing new, innovative and multidisciplinary approaches to teaching and learning, stimulating entrepreneurship and entrepreneurial skills of higher education teaching staff and company staff and facilitate the exchange, flow and co-creation of knowledge. In detail the project will develop:- A common body of knowledge on industry 4.0 readiness/maturation of regions/business and related impact on skills shifting, up/re-skilling (a blueprint for cooperation with and for HEIs, businesses and governments)- Innovative lessons on core topics/main components of the Industry 4.0, targeting students enrolled in HE bachelors/master degrees- Continuous training programmes/short-courses on core topics/main components of the Industry 4.0, targeting employees that are interested in re/upskilling their competences- A joint post-graduation course built-on creative strategies applied to industry 4.0, targeting workers interested in putting into practice pilot projects to accelerate their company’s digital transformation- Guiding and supporting resources targeted to HEIs, business and government decision-making bodies and to educators/trainers - A robust virtual teaching and learning factory for industry 4.0 populated with tools and resources enabling direct contact of the target-groups with the main components of industry and education 4.0, and complemented by physical facilities/equipment, aimed at supporting the development of the hands-on-experiment and pilot projects.