In the last two decades, and particularly since the onset of the global financial crisis, providing innovation-oriented knowledge has become a priority at Higher Education Institutions (HEIs) to address the widespread challenges of high unemployment towards smart and inclusive growth.At the global level, Asia is undergoing rapid changes and integrating into fast-evolving networks but growth is severely uneven, with extremely diverse trajectories in societal and economic development. The socio-economic landscape of the PCs targeted by Hub4Growth (Cambodia, Vietnam, Nepal and Mongolia) shows countries with an urgent need for action at university level to increase innovation related capabilities and link more effectively knowledge produced with market opportunities, therefore promoting socio-economic integration in the coming years.Within this framework, Hub4Growth aims at boosting target PC HEIs’ capacities for entrepreneurship opportunities and structures towards economic development and employability. The project, in line with regional and institutional priorities of the participating PC HEIs, will promote good practices for setting business interfaces in universities, enhance human resources’ capacities, provide for coherent information and communication strategies amongst the universities and within the local business environment. It will also give necessary strategic input for the creation of long-term partnerships and collaborative innovation-related initiatives with enterprises.