The educational curriculum seems to not successfully match with the 21st century skills requirements.In order to develop a student-centered learning environment, cover successfully the needs of a growing diverse population of students in China, India and Cambodia with a variety of multi-cultural, multi-linguistics and multi-ability needs and respond to the gap in skills set in the labour market and society, shortage of qualified teachers and poor level of student learning this proposal aims at modernizing the academic curricula, transferring knowledge and best practices on innovative and ICT-based teaching methodology on 21st skills acquisition from HEIs in Programme Countries to the HEIs of Partner Countries that will be benefited directly from this project. The results include 21st century skills teaching state-of-the-art report, a 21st century skills Educational Programme that will be incorporated in the academic program, capacity-building sessions for Faculty staff and development of 21stTeachSkills e-toolbox and learning Platform. Impact will be generated in institution-level, regional level through dissemination activities and networking and European level with the supprt of the EU-HEIs.