The TAME project has introduced innovative pedagogy methods that provide training for students against medical error (TAME). TAME innovates curricula towards teaching and learning in safe environment and closer to the needs of the real practice, where medical errors occur. With achievement of TAME’s objectives, a great need for the changes in the national healthcare systems will be fulfilled. The training methodologies have been improved, in order to minimise morbidity and mortality resulting from medical errors. Thus, healthcare costs will decrease, the quality of therapy will increase and the public trust in physicians and medicine will be enhanced. TAME’s view is multidimensional. The training is organized into 3 fundamental dimensions: (i) teaching methods, (ii) means of curriculum delivery, (iii) learning outcomes. The multidimensional approach can be used also after TAME’s period in restructuring campus-based teaching towards closer relevance to clinical practice and with patient safety central to undergraduate medical education. The resulting innovated medical curricula are consistent with the efforts of the accreditation councils for graduate medical education as well as of the national expert medical associations. Medical schools play key roles in resolving all barriers that may hinder transparency and full disclosure of medical errors. Training against medical errors will serve as the basis for enhancing patient-doctor relationships, limiting further harm and improving overall health-care safety.