For the third and fourth edition of “Life is Science” the Austrian Centre of Industrial Biotechnology plans to extend its thematic focus on life sciences to the topic of digitization and has initiated a cooperation with St. Pölten University of Applied Sciences. Together, an open event for the general public in the frame of the European Researchers’ Night is planned in Austria: Life is Science in a Digital World (LiS-Dig). Visitors will gain insights into the every-day work of researchers in the disciplines of life sciences and digitization and their impacts on our daily life. The event offers the participants to discover scientific contents along the following dedicated story lines: Health & Food, Climate & Environment, Culture & Community and Digital Transformation. Visiting laboratories and organizations, putting hands on, discussing with scientists, contributing to open innovation and citizen science and watching demonstrations, the participants will dive into recent scientific discoveries. The "Researchers at School" activities (workshops in school classes) will provide an increased flexibility for schools to attend the event independently from the main events in 2022 and 2023. The envisaged activities aim to allow visitors to identify the connection between research and our daily life. To drive participants’ motivation to be active at LiS-Dig, they will have the possibility to win some gifts (hotel vouchers, book vouchers, experimental kits etc). In this way, some may discover their passion for science and their preference for a research career.