Epilepsy, a chronic neurological disorder affecting millions worldwide, necessitates innovative diagnostic and treatment approaches. In this context, sound-based interventions stand as a non-invasive and patient-friendly complement to traditional methods. Nevertheless, the potential impact of sound on this condition remains insufficiently explored, representing a missed opportunity for improvement. This grant proposal aims to fill this gap by exploring the transformative possibilities of sound-to-brain mapping within epilepsy research, with the goal of reshaping both diagnostic procedures and treatment options. While it is well-established that auditory emotions can influence seizure occurrence, the intricate interplay between sound, emotions, and epilepsy has been underinvestigated. This research initiative holds two primary objectives: firstly, to investigate epilepsy by harnessing sound's capability to modulate neuronal excitability, thus shedding light on diagnostic enhancements. Secondly, to explore the therapeutic potential of complex musical sequences for seizure control. This multidisciplinary approach combines aspects of affective neuroscience, music science, and neurotechnology, promising innovative solutions for epilepsy management. By integrating emotional assessments, objective physiological measurements, and cutting-edge EEG tools, we aim to not only improve our comprehension of epilepsy but also to develop home-based solutions for diagnosis, patient follow-up, intervention, and lay the foundation for future clinical trials using portable EEGs, ultimately translating these advancements to the patients.