In-depth knowledge of the consequences of interaction of biomolecules with ionizing radiations is of fundamental importance for progress in medicine, radiotherapy and radioprotection as well as for addressing the panspermia hypothesis. The physicochemical events taking place during the first picoseconds after irradiation have so far escaped the scrutiny of researchers. Yet the plethora of vibrationally hot, electronically excited and highly reactive species formed upon irradiation is likely to trigger rich and non-conventional chemistry. For complex biostructures such as DNA or proteins irradiation could undergo currently unknown chemical damages with dramatic consequences for health. In the field of astrochemistry, ionizing radiations could have played a crucial role. The bombardment of the early Earth by comets that have captured organic rich interstellar icy grains is thought to have provided the molecular precursors at the origin of life on Earth. Such an assumption depends on the survival of these precursor under cosmic irradiations. We will thus explore the early steps of radiation induced damages on biomolecules from first-principles atomistic simulations. RUBI will result in innovative simulation techniques available for the community and is expected to have a great impact on the fundamental understanding of the early steps following matter irradiation, a hot topic in many different research fields. The chemical physics following irradiation of matter produces a plethora of extremely aggressive and unstable chemical species that may directly damage molecules. The reactivity within the ultrafast (