
Understanding the brain and its dysfunctions is one of the major scientific and medical challenges of this new century. This endeavour relies on very diverse, extremely rich and complementary experimental approaches encompassing computational modelling, in vivo and in vitro experiments up to human neurosciences and pre-clinical and clinical studies. Among the great diversity of animal models used to study brain functions, non-human primates (NHPs) are crucial to understand the complexity of primate brains, and to bridge in vivo studies with pre-clinical and clinical studies in humans. For obvious phylogenetic reasons, NHPs are a model of choice for the study of integrative brain functions, that is to say the understanding of how specific cognitive functions are implemented in the brain, how these functions interact with other brain functions and how they can be disrupted following lesions, depletion of certain neuromodulators or just the mere fact of aging. The focus of the consortium is to form a European network to train a new generation of PhD students, with the scope of bringing non-human primate integrative neuroscience research to a new level of excellence thanks to cutting edge innovative methodological combinations. The MRSEI funding will have a fundamental impact on the elaboration of this European project. The MSCA Innovative Training Network project will build on the existing strengths of highly qualified partners from several European countries and develop a network of excellence with complementary capacities in the field of NHP research. It will also emphasize the essential role of industrial and clinical partners for translating technical and clinical advances from NHP primate research to human applications. Currently, the training of PhD students in NHP neuroscience is too often limited to the academic environment with very incomplete access to private companies and clinical practice. This situation is particularly damaging since on the one hand, NHP research is closely dependent upon technological advances and their potential use in human and on the other hand, private companies and clinicians are seeking for trained researchers for collaborations or integration in the private sector. In this context, we are convinced that a networked academic and private public partnership at the PhD level is the most efficient approach to tighten the links between fundamental and applied research. To reach this goal the project proposes frequent training workshops and network meetings in which industrial and clinical partners play a leading role. These will promote innovative methodologies for the design of experiments, technological developments for neuroscience research, tools for trouble shooting and data analysis, translation of NHP research to clinical settings and will aim to enhance the economic impacts of NHP research. In line with the objectives of the MSCA ITN this project will also have a profound impact at the levels of scientific networking and European Policy making. Importantly, in the context of the current European concerns on animal research, this innovative training network will offer the opportunity for PhD students to be educated to the best practice in NHP research, to share their own experience with others and to anticipate rather than to catch up with future progress on these issues. It will emphasize the importance of a thorough education for the development of excellent scientific and ethical competences. As an outcome, young researchers will feel more confident to discuss with the public about the societal impacts of their research for the present and future generations. Altogether, this approach will ensure that Europe will continue to lead the world research for the understanding of brain function in health and disease, including non-human primate neuroscience research performed by scientists with optimal training in practices with the highest scientific and ethical standards.

Understanding the brain and its dysfunctions is one of the major scientific and medical challenges of this new century. This endeavour relies on very diverse, extremely rich and complementary experimental approaches encompassing computational modelling, in vivo and in vitro experiments up to human neurosciences and pre-clinical and clinical studies. Among the great diversity of animal models used to study brain functions, non-human primates (NHPs) are crucial to understand the complexity of primate brains, and to bridge in vivo studies with pre-clinical and clinical studies in humans. For obvious phylogenetic reasons, NHPs are a model of choice for the study of integrative brain functions, that is to say the understanding of how specific cognitive functions are implemented in the brain, how these functions interact with other brain functions and how they can be disrupted following lesions, depletion of certain neuromodulators or just the mere fact of aging. The focus of the consortium is to form a European network to train a new generation of PhD students, with the scope of bringing non-human primate integrative neuroscience research to a new level of excellence thanks to cutting edge innovative methodological combinations. The MRSEI funding will have a fundamental impact on the elaboration of this European project. The MSCA Innovative Training Network project will build on the existing strengths of highly qualified partners from several European countries and develop a network of excellence with complementary capacities in the field of NHP research. It will also emphasize the essential role of industrial and clinical partners for translating technical and clinical advances from NHP primate research to human applications. Currently, the training of PhD students in NHP neuroscience is too often limited to the academic environment with very incomplete access to private companies and clinical practice. This situation is particularly damaging since on the one hand, NHP research is closely dependent upon technological advances and their potential use in human and on the other hand, private companies and clinicians are seeking for trained researchers for collaborations or integration in the private sector. In this context, we are convinced that a networked academic and private public partnership at the PhD level is the most efficient approach to tighten the links between fundamental and applied research. To reach this goal the project proposes frequent training workshops and network meetings in which industrial and clinical partners play a leading role. These will promote innovative methodologies for the design of experiments, technological developments for neuroscience research, tools for trouble shooting and data analysis, translation of NHP research to clinical settings and will aim to enhance the economic impacts of NHP research. In line with the objectives of the MSCA ITN this project will also have a profound impact at the levels of scientific networking and European Policy making. Importantly, in the context of the current European concerns on animal research, this innovative training network will offer the opportunity for PhD students to be educated to the best practice in NHP research, to share their own experience with others and to anticipate rather than to catch up with future progress on these issues. It will emphasize the importance of a thorough education for the development of excellent scientific and ethical competences. As an outcome, young researchers will feel more confident to discuss with the public about the societal impacts of their research for the present and future generations. Altogether, this approach will ensure that Europe will continue to lead the world research for the understanding of brain function in health and disease, including non-human primate neuroscience research performed by scientists with optimal training in practices with the highest scientific and ethical standards.
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