Wild bees provide essential ecosystem services by pollinating the majority of flowering plants. Moreover, society is becoming increasingly dependent on bees as demand for pollinator-dependent crops expands globally. However, many bee populations are declining around the world, in large part due to interaction between multiple environmental stressors including pathogen spread, air pollution and climatic changes. All these stressors are likely to impact the physiology of wild bees. Especially, they can affect their oxidative status by increasing the production of reactive oxygen species. Bee endogenous antioxidant system may then be overwhelmed, which can lead to oxidative stress and give rise to structural and functional damage, potentially causing death. However, the ingestion of exogenous dietary antioxidants should allow for recovering an optimal antioxidants/pro-oxidants balance and then attenuate the damaging effects of stressors (self-medication). Regulation of oxidative stress using dietary antioxidants could therefore be one of the key mechanisms determining the capacity of organisms to cope with living in a changing world. As such, there is a clear need to understand how pollen antioxidants could contribute to the resilience of bees to global changes. The proposed research aims to demonstrate whether conditions for self-medication to counter oxidative stress occur in wild bees to face global changes. The project will rely on innovative methods in ecology, analytical chemistry, metagenomics, proteomics and microbiology. This approach translates the multidisciplinarity and the comprehensiveness of my research activities. The expected results could greatly improve pollinator conservation programs by proposing nature-based solutions, such as promoting a medicative flora.