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Método y sistema para el análisis de analitos mediante transducción de resonancia mecánica

Authors: Gil-Santos, Eduardo; Ruz Martínez, José Jaime; Malvar, Óscar; Tamayo de Miguel, Francisco Javier; Calleja, Montserrat;

Método y sistema para el análisis de analitos mediante transducción de resonancia mecánica

Abstract

Sistema para el análisis de analitos mediante transducción de resonancia mecánica, adecuado para su uso en la identificación de células, bacterias, virus, proteínas o nanopartículas en el intervalo de frecuencia entre 1 MHz y 0 GHz, en donde dicho sistema comprende: a) al menos un sensor de resonador mecánico (2) que comprende unos medios para recibir al menos un analito (1) dispuesto sobre este, en donde dicho analito (1) posee al menos un modo de vibración mecánica (1') y dicho sensor de resonador mecánico (2) posee al menos un modo de vibración mecánica (2') seleccionable en una o más frecuencias de trabajo; b) unos medios para monitorizar los espectros mecánicos del sistema acoplado conformado por el analito (1) y el sensor de resonador mecánico (2); c) unos medios para seleccionar una frecuencia de trabajo del modo de vibración mecánica (2') del sensor de resonador mecánico (2), de tal manera que la constante de acoplamiento κ entre el modo de vibración mecánica (2') del sensor de resonador mecánico (2) y el modo de vibración mecánica (1') del analito (1) sea mayor que 1/(3Q), donde Q es el factor de calidad del sensor de resonador mecánico (2). [ES]

The invention relates to a method and a system of mechanical resonance transduction for analyte analysis, suitable for its use in the identification of nanoparticles in the range between 1 MHz and 300 GHz, said method being characterized in that it comprises the following steps: a) disposing at least one analyte (1), possessing at least one mechanical vibration mode (1'), on at least one mechanical resonator sensor (2) that possesses at least one mechanical vibration mode (2'), selectable in a plurality of working frequencies; b) monitoring the mechanical spectra of the of the analyte (1) and the resonator sensor (2); c) varying the at least one mechanical vibration mode (2') until at least one mechanical vibration mode (2') reaches a strong coupling situation with the at least one mechanical vibration mode (1'); d) collecting the frequency data at which the strong coupling occurs; e) estimating the resonance frequency and quality factor of the at least one mechanical vibration mode (1') from the strong coupling frequency data obtained in step d). [EN]

Consejo Superior de Investigaciones Científicas (CSIC)

T3 Traducción de patente europea

Peer reviewed

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average