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handle: 10261/167899
[EN] The aberrant reactivation of developmental programmes leads to the generation of several adult pathologies. Snail transcription factors are a paradigmatic example, as they are crucial for the development of multiple tissues in the embryo while they can initiate the metastatic cascade in tumours and the development of organ fibrosis and bone pathologies in the adult.
[ES] La activación aberrante de procesos del desarrollo embrionario en el adulto da lugar a distintas patologías. Un ejemplo paradigmático lo constituyen los genes Snail, necesarios para la formación de numerosos tejidos embrionarios e iniciadores de la progresión tumoral hacia la metástasis y de la aparición de fibrosis y de patologías óseas.
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