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Integration of proteomic and metabolomic analyses: new insights for mapping informal workers exposed to potentially toxic elements

Authors: Araujo, Alda Neis Miranda; Leroux, Isabelle Nogueira; Furtado, Danielle Zildeana Sousa; Ferreira, Ana Paula Sacone da Silva; Batista, Bruno Lemos; Silva, Heron Dominguez Torres; Handakas, Evangelos; +2 Authors

Integration of proteomic and metabolomic analyses: new insights for mapping informal workers exposed to potentially toxic elements

Abstract

Occupational exposure to potentially toxic elements (PTEs) is a concerning reality of informal workers engaged in the jewelry production chain that can lead to adverse health effects. In this study, untargeted proteomic and metabolomic analyses were employed to assess the impact of these exposures on informal workeres' exposome. Proteomics analyses were perfomed for saliva samples (n=26), and metabolomic analyses in plasma (n=145) using ultra-high liquid chromatography (UHPLC) coupled with quadrupole-time-of-flight (Q-TOF) mass spectrometry.

Keywords

proteomics, metabolomics, exposome, potentially toxic elements, informal work, occupational exposure, multi-omics

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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