This study investigates the efficacy of gonyautoxin in treating chronic anal fissures. The results show that gonyautoxin is a safe and effective treatment option for this condition. The use of gonyautoxin has been reported to be effective in healing acute and chronic anal fissures, and this study aims to further explore its potential in treating chronic anal fissures. The study's findings suggest that gonyautoxin may be a viable treatment option for patients with chronic anal fissures, and further research is needed to confirm its efficacy and safety.