The Notch pathway plays a key role in stimulating mammalian cell fate decisions. This pathway is crucial for the development and maintenance of various tissues and organs. Epigenetic modifications at Notch responsive promoters can significantly impact the activity of this pathway, leading to changes in cell fate decisions and tissue development. Understanding the mechanisms of epigenetic modification at Notch responsive promoters is essential for developing novel therapeutic strategies for diseases related to Notch pathway dysregulation.