CONNEXION identifies and addresses critical connections between water management and human health in the Inkomati-Usuthu water management area (South Africa). We combine disease and water-energy-food (WEF) interaction models to better understand these connections. We visualise results in a dashboard for decision making, supporting WEF and health managers in their policy and daily practice. Our consortium includes a broad team of researchers and practitioners in WEF, nutrition, and infectious diseases, who will work together with various local stakeholders to co-create potential scenarios and recommendations. CONNEXION will contribute to improved resilience, community livelihoods, health, and wellbeing in the research area and beyond.