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University Of Bristol

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University Of Bristol

391 Projects, page 1 of 79

  • Electrophysiological investigation of the link between M1 muscarinic receptor activation and enhanced NMDA receptor function.

    assignment_turned_inProject2009 - 2013Partners:University Of Bristol
    Funder: Wellcome Trust Project Code: 088239
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  • Engaging the brain's reward system: A neuroscience-informed games-based approach to teaching and learning

    assignment_turned_inProject2014 - 2018Partners:University of Bristol, University Of Bristol, UNIVERSITY OF BRISTOL
    Funder: Wellcome Trust Project Code: 105472
    Funder Contribution: 324,762 GBP
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  • Molecular mechanisms powering a bacterial toxin injection device.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Open Access Mandate for Publications assignment_turned_inProject2015 - 2017Partners:UNIVERSITY OF BRISTOL, University Of Bristol, University of Bristol
    Funder: Wellcome Trust Project Code: 104634
    Funder Contribution: 750,000 GBP
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  • High resolution electron microscopy studies of the Shigella T3SS needle distal tip complex.

    assignment_turned_inProject2008 - 2011Partners:University of Bristol, University Of Bristol, UNIVERSITY OF BRISTOL
    Funder: Wellcome Trust Project Code: 082398
    Funder Contribution: 107,471 GBP

    T3SSs are widely distributed virulence determinants of Gram-negative bacteria. They translocate bacterial proteins into host cells to manipulate them during infection. Only upon direct physical contact with host cells are T3SSs activated to secrete their effectors of virulence. T3SSs are composed of a cytoplasmic secretion machinery and a region spanning both bacterial membranes into which a hollow needle is embedded, protruding from the bacterial surface. The needle is the secretion channel and also directly involved in regulating secretion, probably by transmitting the host cell-detection signal. The needle distal tip seems to be the host cell sensor and then forms the translocation pore within the host membrane. We here aim to understand the detailed structure of the needle tip before and during host cell sensing and translocon insertion so as to be able to deduce how it structurally senses, transmits and responds to the host-cell contact signal. This can be broken down into: Vis ualisation of the Shigella tip complex (TC) in different functional states; Determination of the precise arrangement of components in the resting TC; Development of a highly detailed view of how the TC interacts with the needle.

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  • Dynamic cell biology programme

    assignment_turned_inProject2010 - 2015Partners:UNIVERSITY OF BRISTOL, University Of Bristol, University of Bristol
    Funder: Wellcome Trust Project Code: 093548
    Funder Contribution: 143,090 GBP
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