Osteoporosis is a disease of the bone which affects 3M people in the UK, is associated with 300,000 fractures per year, and costs the NHS £1.9B/yr (figures provided by the National Osteoporosis Society, 2015). Current medical practice is to diagnose osteoporosis and provide pharmacological treatment only after a fragility fracture has occurred. This project seeks to revolutionise treatment through a drug-free, proactive management, through use of precision nanovibrational stimulation applied via bone conduction (similar to bone conduction headphones). Nanovibrational stimulation has recently been shown to produce osteoblasts (bone building cells) in the lab from mesenchymal stem cells (MSCs - adult stem cells found in the bone and elsewhere in the human body). This was the first time that osteogenesis (promotion of bone) has been observed in MSCs without the requirement for drugs and/or complex engineered scaffolds. Since osteoporosis has been linked to insufficient osteogenesis in MSCs, nanovibrational stimulation could provide a breakthrough route to decrease the onset, or perhaps even reverse the effects, of osteoporosis. In order to evaluate this in a timely manner, this project will study disuse-related osteoporosis (due to spinal injury) since this provides a time-accelerated model for testing interventions. The academic team will work alongside the clinicians within the Scottish Centre for Innovation in Spinal Cord Injury (SCISCI) in the Queen Elizabeth National Spinal Injuries Unit and conduct the first trials in nanovibrational stimulation for proactive treatment of osteoporosis.

Remaking Society will be: 1) Working with local partners in demonstrating and assessing participatory cultural activities in four contrasting contexts of deprivation - Bradford, Glasgow, Fraserburgh and Newcastle. 2) Using these four pilots to generate new forms of evidence about the lived experience of poverty and exclusion. 3) Creating opportunities for marginalised and less visible sections of society to communicate with wider audiences, including policy-makers. In this project, the concept of community is not restricted to communitarian accounts of 'a group of people in a given place', or as a site of consensus and constructed oneness based on social categories such as race, class, gender or location. Ours is a dynamic model in which community formation is seen as a continual re-negotiation of co-existence and interdependence, not confined by place, as illustrated by the thirty years of pioneering work by Southall Black Sisters. Questions about how communities conduct these negotiations become particularly important now, at a time of economic crisis, when resources are scarce and stress levels among vulnerable individuals are high. The study will make critical connections between our understanding of community performance and participatory process across academic fields - including conflict resolution, cultural geography, public health, social psychology and sociology. It will allow a re-examination of inter-disciplinary concepts of community through arts and media practices. Belonging to a community is critical to a sense of wellbeing for individuals and families, particularly significant for those who live on the breadline. The second element of Remaking Society is the generation of narrative evidence on the cultural dimensions of poverty and social exclusion. It will add a unique inter-disciplinary arts and humanities perspective to the ESRC's national study, Poverty and Social Exclusion in the UK (www.poverty.ac.uk). Running until 2013, it is the UK's largest ever research project on the impact of poverty.

Speech Sound Disorders (SSDs) are the most common communication impairment in childhood; 16.5% of eight year olds have SSDs ranging from problems with only one of two speech sounds to speech that even family members struggle to understand. SSDs can occur in isolation or be part of disability such as Down syndrome, autism or cleft palate. In 2015, the James Lind Alliance identified improving communication skills and investigating the direction of interventions as the top two research priorities for children with disabilities. Our programme of research aims to fulfil this need by developing technology which will aid the assessment, diagnosis and treatment of SSDs. Currently in Speech and Language Therapy, technological support is sparse. Through our previous work in the Ultrax project we showed that by using ultrasound to image the tongue in real-time, children can rapidly learn to produce speech sounds which have previously seemed impossible for them. Through this project, we developed technology that enhances the ultrasound image of the tongue, making it clearer and easier to interpret. Ultrax2020 aims to take this work forward, by further developing the ultrasound tongue tracker into a tool for diagnosing specific types of SSDs and evaluating how easy it is to use ultrasound in NHS clinics. The ultimate goal of our research is that Ultrax2020 will be used by Speech and Language Therapists (SLTs) to assess and diagnose SSDs automatically, leading to quicker, more targeted intervention. Normally speech assessment involves listening to the child and writing down what they say. This approach can miss important subtleties in the way children speak. For example, a child may try to say "key" and it may be heard as "tea". This leads the SLT to believe the child cannot tell the difference between t and k and select a therapy designed to tackle this. However, ultrasound allows us to view and measure the tongue, revealing that in many cases children are producing imperceptible errors. In the above example, an ultrasound scanner placed under the chin shows that the child produces both t and k simultaneously. Identification of these errors means that the SLT must choose a different therapy approach. However, ultrasound analysis is a time consuming task which can only be carried out by a speech scientist with specialist training. It is a key output of Ultrax2020 to develop a method for analysing ultrasound automatically, therefore creating a speech assessment tool which is both more objective and quicker to use. Building on the work of the Ultrax project, where we developed a method of tracking ultrasound images of the tongue, Ultrax2020 aims to develop a method of classifying tongue shapes to form the basis of an automatic assessment and a way of measuring progress objectively. We are fortunate to already have a large database of ultrasound images of tongue movements from adults and primary school children, including those with speech disorders, on which to base the model of tongue shape classification and to test its performance. At the same time, we will evaluate the technology we develop as part of Ultrax2020 by partnering with NHS SLTs to collect a very large database of ultrasound from children with a wide variety of SSDs. In three different NHS clinics, SLTs will record ultrasound from over 100 children before and after ultrasound-based speech therapy. This data will be sent to a university speech scientist for analysis and feedback to clinicians recommending intervention approaches. Towards the end of the project, we will be able to compare this gold-standard hand-labelled analysis with the automatic classification developed during the project. At the conclusion of our research project we will have developed and validated a new ultrasound assessment and therapy tool (Ultrax2020) for Speech and Language Therapists to use in the diagnosis and treatment of SSDs.

Osteoporosis and osteoarthritis affect millions of patients around the world and are eventually characterised by a reduction of bone strength that results in increased rates of fractures. Life expectancy continues to rise but patient specific treatment solutions to optimally manage those patients are sill not available. Such solutions could consist of tailored medication strategies and, at a later stage, tailored implant solutions which require a thorough understanding of the mechancial competence of structural tissue. While the mechanical behaviour of bone is currently well characterised at the upper level of tissue organisation, the underlying nonlinear mechanical properties of mineralised collagen fibre assemblies, however, remain obscured by structural features such as cellular porosity, lamellar organisation, cement lines, cracks and other interfaces. Starting from preliminary pilot experiments, this proposal aims at performing simultaneous uniaxial micropillar strength tests and structural measurements using small-angle X-ray scattering and wide-angle X-ray diffraction on micron-sized volumes of the extra-cellular matrix (ECM) and, thus, on mineralised collagen fibre assemblies only. This project will result in a versatile and powerful experimental framework that will be used to understand the structure-mechanics relation of ECM with an unprecedented spatial resolution of the mechanical experiment. The results of this project will inform the engineering of patient-specific material solutions in silico through all relevant length scales starting from the ECM level. This, in turn, will foster the development and realisation of production technologies for manufacturing patient-specific "implants on demand" which could be offered as a service or embedded in a hospital. The novel experimental techniques may be useful for testing and developing functional thin films such as implant coatings, investigating the impact of pathological changes on the ECM, or even to reduce, refine, and replace animal experiments.

Connect2 is a 138 million investment programme in walking and cycling infrastructure at 79 sites across the UK that provides a unique opportunity to determine the impact of infrastructure provision on walking and cycling and to assess the impact of other interventions including promotional activities. The challenge is to ensure this opportunity is used to fill evidence gaps, assess transferability and influence policy. The aim of this project is therefore to measure and evaluate the travel, physical activity and carbon impacts of interventions to improve the connectivity of infrastructure for walking and cycling. To achieve this aim we have developed an interdisciplinary consortium of eight institutions with expertise in energy, environmental, physical activity, public health and transport research, as well as computerised urban modelling. Our objectives are: (1) to develop and refine measurement instruments and evaluation frameworks for assessing the effects of these interventions on travel activity, physical activity and carbon emissions; (2) to apply these methods in longitudinal population-based studies at a purposive sample of up to six Connect2 case study sites; (3) to determine the likely benefits of additional promotional interventions using a randomised controlled trial at one Connect2 site (provisionally the Road to Nowhere scheme in Glasgow); and (4) to enhance and collate data at all Connect2 sites to develop strategic evaluation measures. Our methodological approach will be informed by the realist approach to evaluation which advocates determining not simply whether an intervention has worked but also understanding why it is effective (or not), in what ways, for whom and in what circumstances. We will therefore collect data on context, mechanisms and outcomes using a longer self complete household questionnaire, to which we anticipate a total of approximately 10,000 useable responses from the main case studies; a shorter user intercept questionnaire, developed in conjunction with Sustrans; and more detailed objective measures from subsets of our study cohorts. The main outputs will be an improved set of measurement and evaluation tools at the strategic and more detailed, local levels, validated using a heterogeneous set of Connect2 case studies; evidence on the impacts of infrastructural and promotional interventions, which will inform policy and practice; and strategic benefit and cost measures which will inform and influence government policy and appraisal of infrastructural interventions. These outputs will have significant generic benefits for central government, local authorities, active travel users and academia.