AIRIS will develop the next generation of multimodal Generative AI (GenAI) models to accelerate research on predictive and personalised medicine. Building on recent advances in LLMs, causal inference and mechanistic modelling, AIRIS will integrate heterogeneous biomedical data (omics, imaging, clinical, laboratory, lifestyle, PROMs and scientific literature) into mechanism-informed generative frameworks. These models will not only generate biologically plausible synthetic data to address sparsity and bias but also embed causal and dynamical constraints across biological scales, from “virtual cells” to multi-organ models, enabling counterfactual reasoning and in-silico hypothesis testing. The project will deliver (i) robust agentic multimodal data integration pipelines; (ii) novel mechanism-anchored generative architectures with interpretability and bias-mitigation safeguards; (iii) hypothesis generation assistants for biomarker discovery, drug repurposing, and intervention design; and (iv) a scalable MLOps infrastructure ensuring reproducibility. AIRIS will be validated using already existing large-scale datasets in five high-impact use cases including Pulmonary Fibrosis, Steatotic Liver Disease, Cardiovascular Disease, Chronic Kidney Disease and Inflammatory Bowel Disease. AIRIS will demonstrate utility in modelling of disease, while also allowing cross-disease insights. A multidisciplinary consortium spanning leading universities and research centres, HPC experts, industry, and SME ensures excellence across the project dimensions. ELSI and fairness will be systematically addressed by SSH and legal experts. Outputs will be openly disseminated through benchmarks, training, and open-source releases, fostering European leadership in mechanism-informed GenAI. AIRIS will maximise scientific, clinical, and societal impact by bridging AI innovation with biomedical discovery, improving disease understanding, and supporting equitable personalised care.

The European Rare Diseases Research Alliance (ERDERA) aims to improve the health and well-being of the 30 million people living with a rare disease in Europe, by making Europe a world leader in Rare Disease (RD) research and innovation, to support concrete health benefits to rare disease patients, through better prevention, diagnosis and treatment. This Partnership will deliver a RD ecosystem that builds on the successes of previous programmes by supporting robust patient need-led research, developing new diagnostic methods and pathways, spearheading the digital transformational change connecting the dots between care, patient data and research, while ensuring strong alignment of strategies in RD research across countries and regions. Structuring goal-oriented public-private collaborations targeted at interventions all along the R&D value chain will ensure that the journey from knowledge to patient impact is expedited, thereby optimising EU innovation potential in RD. To support its ambition and missions ERDERA has been designed as a comprehensive and integrated ecosystem of which structure can be compared to an institute encompassing three main parts: (i) funding, (ii) internal (in house) Clinical Research Network that implements research activities targeting clinical trial readiness of RDs and accelerating diagnosis and translation of research discovery into improved patient care, and (iii) related supporting services (Data, Expertise, Education and Training) as well as an acceleration hub that serve external and internal RD community, all supported by all-embracing coordination and strategy and foundational (inter)national alignment.

MINDtheGEPs takes a multidisciplinary multidimensional approach to challenging gender unbalances across five different countries with still traditional gender regimes (Italy, Spain, Serbia, Ireland, Poland) and across various types of Research Performing Organisations: 4 public universities (Turin, Tralee, Gdansk, Jagiellonian) and 1 public non-academic research institute (CNR); 1 academic (Belgrade) and 1 private technological institute center (Galicia). The consortium, led by the University of Turin’s CIRSDe, comprises also three non-implementing organizations bringing complementary expertise in monitoring and evaluation (Knowledge and Innovation), research communication (Uppsala University) and scientific publishing (Elsevier). In order to promote systemic institutional change and following the “no data-no policy” principle, the project will map the existing data and, building on the tools developed within an ongoing research project of the project coordinator, will produce new quali-quantitative evidence. On this basis, both structural and cultural actions can be effectively designed. At cultural level, the project will organize a virtuous chain of trainings, starting from across-partners "train the trainers" workshops to within-partners laboratories addressed to young women, but, endorsing the approach of "fixing the system not the women", also to men and senior researchers. At structural level, the project will introduce work-family measures addressed also to men, equality targets in decision-making boards and gender-sensitive research. The establishment of proper figures and bodies creates conditions for the endurance of GEPs beyond the project’s life. A multidisciplinary team (also including key-persons in middle or top management), coupled with a multi-skilled Advisory Board (including relevant national authorities), and 4 professional associations both in STEMM and SSH, will contribute to a successful change in RPOs and in society at large.