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UAAAN

Universidad Autónoma Agraria Antonio Narro
1 Projects, page 1 of 1
  • Funder: French National Research Agency (ANR) Project Code: ANR-11-ISV7-0001
    Funder Contribution: 277,496 EUR

    Ungulates (sheep, goats...) have a seasonal breeding characterised by a period of sexual activity (short-dayd period, november-april) followed by a period of sexual rest (or anestrus period, long-days period, may-october). During the season of sexual rest, females are reproductively quiescents and have therefore no ovarian cycle nor ovulation. However, if during this period they are exposed to a male, they will undergo a complete reactivation of their gonadotropic axis measured through LH pulsatility (short-term response) leading to an ovulation (long-term response). This effect is called the "male effect" and is an attractive technique to control ungulate reproduction in a context of clean, green and ethical farm productions development. Indeed, using the male effect is an alternative to the usual administration of exogenous hormones which can act as endocrine disruptors once released in the environment. In addition, this technique is also a low-cost solution to have reproduction during the anestrus season where animal products derived from lambing/kidding (meat, milk...) are present in a limited amount. However, the use of the male effect under breeding conditions is still limited. In this context, our laboratories (Physiologie de la Reproduction et des Comportements, France, Universidad Autonoma Agragrio Antonio Narro, Mexique et Universidad Nacional Autonoma de Mexico) have recently shown (Bedos et al., Hormones & Behavior, accepté) that 4h of daily contact with a sexually active male during 15 days (instead of a permanent contact) is sufficient to induce an efficient male effect, that is a to induce 100% of gestation in female goats. This result opens new perspectives for breeding applications as well as for the neuroendocrine mechanisms involved.This projects is thus dedicated to define the optimal contact parameters (duration of daily contact, number of famels that a male can stimulate...) to perform an efficient male effect in a maximal number of females. In a second part, we want to compare the neuroendocrine mechanisms inducing a whole reactivation of the gonadotropic axis depending on the contact duration (intermittent vs permanent). In this context, we will use different approaches (assay of LH pulsatility, measure of brain activation thourgh functional brain imaging, and neurochemical characterization of neuronal populations by immunocytochemistry).

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