Developing machine learning methods suitable for data-limited systems is a core concern of artificial intelligence (AI) for health which typically suffers from sparse data. One promising approach is to leverage related data-rich systems through transfer learning; for example, by pre-training models that can be fine-tuned for clinical settings. Importantly, however, this approach can degrade performance if target domains have limited data. Human neuroimaging (e.g., functional magnetic resonance imaging [fMRI] data) is one such domain as data points are expensive to acquire and therefore commonly undersampled in clinical populations. In parallel, researchers have invested in creating large repositories of fMRI data from a small number of healthy adult participants with the goal of studying normative brain function. Leveraging these data-rich research samples to augment inferences in clinical samples would thus be highly desirable. We propose to jointly evaluate the feasibility of this approach, leveraging our expertise in information transfer techniques and in developing models of individual fMRI datasets using AI architectures. As research datasets vary along multiple dimensions, we propose to investigate methods to overcome multiple sources of distribution shift, including in population characteristics as well as task. We will build on existing work leveraging Optimal Transport (OT), extending to new across sample alignments. These goals entail the development of novel transfer procedures, either stemming from OT theory at large, or leveraging data structure, e.g. graph convolutional networks. As an extension of these approaches, we will also investigate aggregation through multi-source learning to improve the scalability of these techniques and enhance privacy-preservation. Our proposed work will provide new perspectives on the challenge of domain adaptation with limited target data and create new opportunities to leverage previously unconsidered data sources.

The aim of the IDIH project is to promote and increase international cooperation to advance digital health in the EU and key strategic countries to support active and healthy ageing through innovation. IDIH will identify shared priorities and set up a Digital Health Transformation Forum as a long-lasting and expert-driven catalyst to foster collaboration between the EU and five strategic third countries, i.e. Canada, China, Japan, South Korea and the USA. Overall, the IDIH project sets 4 targeted objectives. First, to support the definition of common priorities to enhance strategic international cooperation in digital health in line with policy orientations through a thorough analysis of priorities in Europe and each of the strategic third countries and close involvement of the relevant funding agencies. Secondly, to provide specific contributions to the international dialogue in digital health with the creation of a Digital Health Transformation Forum acting as umbrella for high-level experts in four thematic groups (Preventive care, Integrated care, Independent and connected living and Inclusive living). Thirdly, to facilitate the exchanges between RTI stakeholders from the EU and strategic third countries in digital health through international workshops, promotion of cooperation opportunities (guidebook, webinars, helpdesk) and joining forces with other initiatives. Fourthly, to foster international collaboration for digital solutions for health care benefitting the society and industry through networking and co-creation sessions in RTI workshops. The consortium partners have complimentary expertise, including healthcare & digital health, IT, H2020 project management, technology transfer etc. The consortium has close links to funding authorities and actors in the Digital Health Industry in all countries/regions and have wide networks in the community. As such, the consortium possesses expertise and tools to successfully realise the objectives of the project.

In our society, deaf children are confronted to the problem of communication with all their surrounding. The technology of cochlear implant gives the possibility to deaf children to access to the comprehension of hearing people and so also to access to oral language to be understood. This technology is used all around Europe, not at the same level, because of the cost, but more and more children can benefit from the cochlear implants. Specialised institutions for deaf ensure the rehabilitation process necessary to improve the comprehension and oral language (multidisciplinary team composed of ENT specialists, neuropsychologists, speech therapists, social workers, etc. )In the same time, the development of this technology has revealed that 30% of the beneficaries can not develop oral language, and so revealed neurolinguistic disorders. It is very difficult to assess and to quantify some of these disorders. The work of specialists requires significant multidisciplinary cooperation and regular observations. This project will enable this collaborative work to give at EU level a better understanding of practices, explorations and materials used in the support of these children. Even though the objective is to produce a protocol of assessment and rehabilitation for a multidisciplinary team to improve the support of these children, this step of explorations is very important to get the good knowledge of the situation in Europe. We will develop two main times of training for participants, one of this event will be to understand the explorations of all the partners and to introduce the question of language disorders to define a consent on the definition. The 2nd one will be more focused on clinical cases, giving a good comprehension of the situation. That will provide a presentation of practices and explorations at EU level, with the implementation of a canadian partner, who get better results in the development of oral language. Their practicies and the North American situation will provide an added-value in the comprehension. In Montreal, Institut Raymond Dewar which follows the children with cochlear implants has pointed out only 3 situations of problems of development of oral language among the 108 deaf children implanted between 2015 and 2018. Such results are great opportunities for our partnership to know more about what is working practically. 20 participants will attend each training event - they will be representative of the question in their organisations and there will be ENT specialists, neuropsychologists, psychologists, social workers, speech therapists, specialised teachers, all the professionals which form the multidisciplinary team in the support of these children. The outcomes of the project will give the possibility to continue in the development of a protocol of assessment and rehabilitation for professionals (participants mentioned) working with these children, in a development of innovation, for the benefit of deaf children and their parents.