Online social networks, news media and web platforms are the way contemporary societies operate for communication, information exchange, business, co-creation, learning and knowledge acquisition . However, the veracity of information circulating in the digital world is often in dispute. Indeed, disinformation and fake news (D&FN) increasingly affect and distort public opinion. National governments and supranational institutions recognize the spread of D&FN as a pernicious social problem. Indeed, the diffusion online of D&FN may have severe consequences. First, the spread of D&FN might infuse uncertainty and fear, intensify the crisis situations, weaken the European societies aggravating their divisions. In turn, the increase in divisions and fear leads to episodes of physical violence offline and other hate crimes. As such, D&FN have the power to polarise public debates and put the health, security, and environment of EU citizens at risk. Finally, the use of fake accounts, the involvement of AI-generated fake content and the use of bots that can spread D&FN at scale pose additional problems. FERMI will exploit a holistic and cross-disciplinary methodology towards a framework that will thoroughly analyse D&FN and their sources, in combination with all the socioeconomic factors that may affect both the spreading of such incidents and their effects on multiple dimensions of society. Comprising a set of innovative technological developments, FERMI will facilitate EU Police Authorities to detect and monitor the way that D&FN spread, both in terms of locations and within different segments of the society, and to put in place relevant security countermeasures; it will produce and diffuse tailor-made training material designed for i) European Police Authorities, ii) other professionals and stakeholders, iii) EU citizens for combating the spread and limiting the impact of D&FN and increasing digital trust.