Biological or molecular catalysts built from Earth-abundant elements are envisioned as economically viable alternatives to the scarce noble metals that are currently used in renewable energy conversion. However, their fragility and O2 sensitivity have been obstacles to their adoption in industry. We have recently proposed O2 quenching matrices for protecting intrinsically O2-sensitive catalysts for use in anodic (oxidative) processes. We have demonstrated that even hydrogenases, the highly sensitive metalloenzymes that oxidize H2, can be used under the harsh conditions encountered in operating fuel cells. However, attempts to reverse the concept for the protection of cathodic (reductive) processes, such as H2 evolution, have been unsuccessful so far. In this case, the electrode generates the reducing agents in the form of electrons, which are needed for both H2 generation and reductive O2 quenching. The competition between the two reactions results in insufficient protection from O2 and deactivation of the catalyst. The objective is to design an alternative electron pathway that relies on H2 as a charge carrier to efficiently shuttle the reductive force to the matrix boundaries and quench the incoming O2. We will develop novel electron mediators with dual functionalities to enable the reversible H2/H+ interconversion and to achieve the complete reduction of O2 to water. We will focus on organic systems, as well as metal complexes based on Earth-abundant elements with tunable ligand spheres, to adjust their redox potentials for the desired direction of the electron flow and toward fast O2 reduction kinetics. The synthetic efforts will be supported by electrochemical modelling to predict the required properties of the redox matrix for efficient protection. After establishing the protection principle, we will demonstrate its practical use for implementing sensitive bio-catalysts for electrochemical H2 evolution under conditions relevant to energy conversion processes.

Tony Skyrme proposed that under special circumstances it is possible to stabilize vortex-like whirls in fields to produce topologically stable objects. This idea, effectively of creating a new type of fundamental particle, has been realised with the recent discovery of skyrmions in magnetic materials. The confirmation of the existence of skyrmions in chiral magnets and of their self-organization into a skyrmion lattice has made skyrmion physics arguably the hottest topic in magnetism research at the moment. Skyrmions are excitations of matter whose occurrence and collective properties are mysterious, but which hold promise for advancing our basic understanding of matter and also for technological deployment as highly efficient memory elements. Following the discovery of skyrmions in a variety of materials, several urgent questions remain which are holding back the field: what are the general properties of the phase transitions that lead to the skyrmion lattice phase, the nature of its structure, excitations and stability and how might we exploit the unique magnetic properties of this matter in future devices? These questions have only recently begun to be addressed by several large international consortia and are far from being resolved. For the UK to contend in this highly competitive field a major project is required that brings together UK experts in materials synthesis and state-of-the-art theoretical and experimental techniques. We propose the first funded UK national programme to investigate skyrmions, skyrmion lattices and skyrmionic devices. Our systematic approach, combining experts from different fields is aimed at answering basic questions about the status of magnetic skyrmions and working with industrial partners to develop technological applications founded on this physics.

The Danube River Basin (DRB) faces significant challenges associated with river sediments. In the 2021 update of the Danube River Basin Management Plan, sediment balance alteration emerged as a new sub-topic within the existing Significant Water Management Issue titled "Hydromorphological alterations." Additionally, sectors like industry, urban sewage, and agriculture call for sediment quality evaluations throughout the DRB. However, the absence of standard sediment monitoring limits our understanding of risks. Addressing the sediment mismanagement in the DRB, the iNNO SED project aims to establish the Danube Sediment ‘Lighthouse’ Knowledge Centre. This centre will: • Introduce a set of innovative methods for monitoring and modelling sediment quantity and quality, thereby deepening our knowledge of sediment processes. • Provide innovative sediment management practices to improve sediment continuity and quality in DRB sections facing with sediment-related issues. • Showcase co-created innovative measures through demonstration activities, while also evaluating their socio-economic and environmental aspects. • Empower the public with innovative knowledge transfer methodologies. • Collaborate with five Associated Regions, transferring the iNNO SED solutions to other river basins. To accomplish these goals, iNNO SED will leverage the achievements and key contributors of the DanubeSediment and SIMONA initiatives. Moreover, it will engage relevant stakeholders of sediment management, such as ICPDR, policy makers, river managers, hydropower plant managers, waterway authorities, national parks, environmental agencies, SMEs, and more. iNNO SED will represent a pioneering approach to sediment management in large international river basins. This approach sets an example for other major global river systems like the Amazon, Mekong, or Niger. In doing so, it aligns with the Mission's objective of intensifying the European Union's competitiveness.