Background We propose a holistic view of interrelated frailties: cognitive decline, physical frailty, depression and anxiety, social isolation and poor sleep quality, which are a major burden to older adults and social and health care systems. Early detection and intervention are crucial in sustaining active and healthy ageing (AHA) and slowing or reversing further decline. Aims and Relevance The main aim of my-AHA is to reduce frailty risk by improving physical activity and cognitive function, psychological state, social resources, nutrition, sleep and overall well-being. It will empower older citizens to better manage their own health, resulting in healthcare cost savings. my-AHA will use state-of-the-art analytical concepts to provide new ways of health monitoring and disease prevention through individualized profiling and personalized recommendations, feedback and support. Approach An ICT-based platform will detect defined risks in the frailty domains early and accurately via non-stigmatising embedded sensors and data readily available in the daily living environment of older adults. When risk is detected, my-AHA will provide targeted ICT-based interventions with a scientific evidence base of efficacy, including vetted offerings from established providers of medical and AHA support. These interventions will follow an integrated approach to motivate users to participate in exercise, cognitively stimulating games and social networking to achieve long-term behavioural change, sustained by continued end user engagement with my-AHA. Scale and Sustainability The proposed platform provides numerous incentives to engage diverse stakeholders, constituting a sustainable ecosystem with empowered end users and reliable standardised interfaces for solutions providers, which will be ready for larger scale deployment at project end. The ultimate aim is to deliver significant innovation in the area of AHA by cooperation with European health care organizations, SMEs, NGOs.

ADAM^2 aims at questioning five decades of traditional paradigms in computer aided design CAD. While the field of CAD has been very successful in the last half a century using boundary representations, the introduction of microstructure into the design-analysis-manufacturing cycle is going to completely revolutionize geometric CAD from the ground up and into the essential volumetric representations, making an unprecedented leap in the quality of manufactured artefact. The evolution of new manufacturing technologies such as multi-material 3D printers gives rise to new type of objects that may consist of considerably less, yet heterogeneous, material, consequently being porous, lighter and cheaper, while having the very same functionality (e.g. stiffness) as the original object when manufactured from one single solid material. We propose a unified manufacturing pipeline that will focus on all stages involving Analysis, Design, And Manufacturing using Microstructures (ADAM^2). ADAM^2 proposes high-risky interdisciplinary research that will combine user-guided shape modelling using microstructures, followed by validation and structural optimization using physical process simulation, and finalized by physical realizations via additive and hybrid manufacturing and its subsequent validation. The results of this project will lead to scientific-technological development that impacts €2B/year CAD and €24B/year tool manufacturing European markets, and are expected to reduce the exploitation of heavy materials between an order of magnitude to two orders, in volume.