The world population living in urban settlements is expected to increase to 70% of 9.7 billion by 2050. Historically, as cities grew, new water infrastructures followed as needed. However, these developments had less to do with real planning than with reacting to crisis situations and urgent needs, due to the inability of urban water planners to consider long-term, deeply uncertain and ambiguous factors affecting urban development and water demand. These, coupled with increasingly uncertain climate conditions, indicate the need for a more holistic and intelligent decision-making framework for managing water infrastructures in the cities of the future. This project aims to develop a new theoretical framework for the allocation and development decisions on drinking water infrastructure systems, so that they are socially equitable, economically efficient and environmentally resilient, as advocated by the UN Agenda 2030, Sustainable Development Goals. The framework will integrate real-time monitoring and control with long-term robustness and flexibility-based pathway methods, and incorporate economic, social, ethical and environmental considerations for sustainable transitioning of urban water systems under deep uncertainty with multiple possible futures. The Water-Futures team will build on synergies from the four research groups, transcending methodologies from water science, systems and control theory, economics and decision science, and machine learning, into an integrated decision and control framework, to be implemented as an open-source research toolbox. The new science outcomes will be applied to three case studies exemplifying different types of urban water systems: a mature, relatively stable system; a mature and rapidly expanding system; and a relatively recent supply system in a developing country with high growth and special challenges, including limited resources, intermittent supply and high water losses.

The INTERfaces program will train 14 ESRs within an EID network jointly designed by European academic and industry partners in innovative research projects dedicated to developing clean bioprocesses for the production of chemicals. The assembly of biocatalysts to reaction sequences allows avoiding steps for isolation and purification of intermediates and thus a significant improvement of the environmental footprint of catalytic processes. The main goal of INTERfaces is the extension of this concept towards multi-step biocatalytic reactions in immobilized form. These “Heterogeneous Biocatalytic Reaction Cascades” will greatly facilitate re-use of the catalysts and further simplify downstream-processing. INTERfaces combines material science and protein engineering to design tailored enzymes and (bio-based) materials that will complement each other to obtain optimized heterogeneous biocatalysts. These tools will be applied to solve synthetic challenges in the use of two biobased monomers as starting materials to synthesize products for application fields like antioxidants and biopolymers. Process optimization and up-scale in industry will reveal key factors for synthetic utilization of the biocatalysts. INTERfaces emphasizes particularly the engineering of the designed cascades in solid phase. This includes the design of reactors, use of computational modeling tools, application of the right operational modes, and reaction medium needed for desired space-time-yields and product titers. Commercial relevant processes will be up-scaled together with industry for technical implementation. 13 Non-academic partners ranging from high-tech SMEs to large producing companies and 9 academic institutions offer an intersectoral and interdisciplinary environment to provide 14 Ph.D. candidates with outstanding employability profiles for the European Biotech Sector. Dedicated workshops and well-balanced supervisory team aim at increasing the gender diversity in biotech research.

Metamaterials (MMs) are man made materials with unusual electromagnetic properties that are not typically found in Nature. They are the key to achieving such extraordinary properties as invisibility cloaks and perfect lenses. At present, they are bulky and confined to laboratories. If they were flexible, they could become much more versatile and practical. Here, I propose a novel concept for flexible MMs that will turn current cloaking devices from suits of armour into true cloaks.The concept of index of refraction underpins the physics of MMs, which can be illustrated with an example. The direction that light takes when it crosses the interface between two media depends on its initial direction with respect to the surface and on the refractive indices of the media. This is the reason why a pencil appears to kink when immersed in water. In nature, all transparent materials have a positive refractive index, like water. As a result, the image of the pencil always kinks in the same direction. Conversely, MM are manufactured with a negative refractive index, thus in a MM the kink of the pencil would appear in the opposite direction. This effect, which may seem to be a mere curiosity, drives the extraordinary behavior of MMs.The technological requirements of currently fabricated optical MMs impose a flat rigid geometry. This impedes the realistic implementations of an optical cloak made of soft fabric, for example. I aim to overcome such limits.The aim of this project is to fabricate MMs in flexible, extremely thin membranes (METAFLEX).Metaflex will retain all the power of material design typical of MMs and their ability to control light, in a more flexible framework. I have already achieved the first milestone of the project and printed MMs on polymer flexible membranes with thickness down to few nanometers.The physics of Metaflex is a rich and unexplored field of research. This ambitious project is structured around their most striking properties:-Metaflex can be wrapped around objects and stacked, a vital step to realistic cloaking applications.-Metaflex stacks can be easily fine tuned after fabrication, e.g. via deformation, hence light can be controlled with additional degrees of freedom. The flexibility of Metaflex permits the design and fabrication of a camouflaging system, as the material response can sense and adapt to the surrounding environment. This offers a remarkable example of smart fabrics and intelligent textiles, currently a thriving area of research in academia and industry.-Metaflex provide a new framework to study the interaction between optical and mechanical forces, as in Optical Trapping or the new field of Optomechanics. Potential applications include very small optical microphones.-Metaflex are very light. They could take advantage of the attractive and repulsive forces triggered by optical beams in order to levitate and behave as nano-flying carpets. This would be a breakthrough in biomedical nano-applications such as drug-delivery and single molecules manipulation.My interest in Metaflex arises from diverse theoretical and experimental projects in photonic structures and nanofabrication and from the knowledge gained throughout these projects, including the physics and applications of MMs. This project contains many exciting scientific challenges, which offer the possibility of developing the extraordinary properties of MMs for every-day life applications that were unimaginable only a few years ago.