The FLEXOP project is about developing multidisciplinary aircraft design capabilities for Europe that will increase competitiveness with emerging markets -particularly in terms of aircraft development costs. A closer coupling of wing aeroelasticity and flight control systems in the design process opens new opportunities to explore previously unviable designs. Common methods and tools across the disciplines also provide a way to rapidly adapt existing designs into derivative aircraft, at a reduced technological risk (e.g. using control to solve a flutter problem discovered during development). The goal will be achieved by: (a) improving efficiency of currently existing wing, by increased span at no excess structural weight, while establishing modifications by aeroelastic tailoring to carry the redesigned derivative wing; (b) developing methods and tools for very accurate flutter modeling and flutter control synthesis, to enable improved flutter management during development, certification, and operation, enabling to fly with the stretched wing at same airspeed as the baseline aircraft; (c) validating the accuracy of developed tools and methods on an affordable experimental platform, followed by a scale-up study, demonstrating the interdisciplinary development cycle. Manufacturers will gain cost efficient methods, tools and demonstrators for enhancing aircraft performance by integrated development of flutter control and aeroelastic tailoring. These inter-disciplinary capabilities will improve the design cycle and the Verification& Validation process of both derivative and new aircraft. Better control of development and certification costs can be achieved if these capabilities are used to address problems early in the design process. Flight test data will be posted on the project website to provide a benchmark for the EU aerospace community. The project’s results will serve as a preliminary outlining of certification standards for future EU flexible transport aircraft.

Collecting and analysing large amounts of data in the Cloud-to-Edge computing continuum raises novel challenges. Processing all this data centrally in cloud data centres is not feasible anymore as transferring large amounts of data to the cloud is time-consuming, expensive, degrade performance and may raise security concerns. Therefore, novel distributed computing paradigms, such as edge and fog computing emerged to support processing data closer to its origin. However, such hyper-distributed systems require fundamentally new methods. To overcome the limitation of current centralised application management approaches, Swarmhestrate will develop a completely novel decentralised application-level orchestrator, based on the notion of self-organised interdependent Swarms. Application microservices are managed in a dynamic Orchestration Space by decentralised Orchestration Agents, governed by distributed intelligence that provides matchmaking between application requirements and resources, and supports the dynamic self-organisation of Swarms. Knowledge and trust, essential for the operation of the Orchestration Space, will be managed through blockchain-based trusted solutions using methods of Self-Sovereign Identities (SSI) and Distributed Identifiers (DID). End-to-end security of the overall system will be assured by utilising state-of-the-art cryptographic algorithms and privacy preserving data analytics. Due to the imminent complexity of the decentralised system, novel simulation approaches will be developed to test and optimise system behaviour (e.g., energy efficiency) in the early stages of development. Additionally, the simulator will be further extended into a digital twin running in parallel to the physical system and improving its behaviour with predictive feedback. The Swarmchestrate concept will be prototyped on four real-life demonstrators from the areas of flood prevention, parking space management, video analytics and a digital twin of natural habitat.

Particle physics is at the forefront of the ERA, attracting a global community of more than 10,000 scientists. With the upgrade of the LHC and the preparation of new experiments, the community will have to overcome unprecedented challenges in order to answer fundamental questions concerning the Higgs boson, neutrinos, and physics beyond the Standard Model. Major developments in detector technology are required to ensure the success of these endeavours. The AIDA-2020 project brings together the leading European infrastructures in detector development and a number of academic institutes, thus assembling the necessary expertise for the ambitious programme of work. In total, 19 countries and CERN are involved in this programme, which follows closely the priorities of the European Strategy for Particle Physics. AIDA-2020 aims to advance detector technologies beyond current limits by offering well-equipped test beam and irradiation facilities for testing detector systems under its Transnational Access programme. Common software tools, micro-electronics and data acquisition systems are also provided. This shared high-quality infrastructure will ensure optimal use and coherent development, thus increasing knowledge exchange between European groups and maximising scientific progress. The project also exploits the innovation potential of detector research by engaging with European industry for large-scale production of detector systems and by developing applications outside of particle physics, e.g. for medical imaging. AIDA-2020 will lead to enhanced coordination within the European detector community, leveraging EU and national resources. The project will explore novel detector technologies and will provide the ERA with world-class infrastructure for detector development, benefiting thousands of researchers participating in future particle physics projects, and contributing to maintaining Europe's leadership of the field.

Brain disorders affect ~179 million people and their families in Europe alone, with an annual cost to the taxpayer estimated at €800 billion- a greater economic burden than cardiovascular disease and cancer combined. Despite diverse etiology, overlap in clinical symptoms and comorbidities between brain disorders suggests shared patho-mechanisms. In particular, hyperexcitible states driven by glial activation and neuroinflammation appear near ubiquitous. Targeting these mechanisms offers the potential to ameliorate symptoms and reverse disease progression across a broad span of brain disorders. Functioning as a gatekeeper to neuroinflammation and mechanistic link between neuronal hyperexcitability and glial activation, the ATP-gated, ionotropic purinergic P2X7 receptor (P2X7R) offers the most promising target for pharmacological intervention in the neuroinflammation-hyperexcitability pathway, to date. With breakthroughs in understanding P2X7R function, highly promising effects demonstrated for antagonists in models of brain disease and vast investment in P2X7R-related drug development programmes, now is the perfect time to pool resources. PurinesDX brings together global leaders in translational research in purinergic signalling, Europe’s leading clinical specialists in a broad range of brain diseases, and industrial partners specializing in drug and biomarker development. Sharing unique genetic tools, newly developed diagnostic devices and novel, selective and brain-stable P2X7R antagonists, the synergism facilitated within PurinesDX will extend to the training of an urgently needed new generation of highly skilled, innovative, creative and entrepreneurial scientists. Alongside the provision of this interdisciplinary, international and intersectoral environment, an original and high level training in state-of-the-art neuroscience will be provided, nurturing a cohort of highly competitive researchers with potential to drive a new era of neuroscience research.