To face human population growth, increasing environmental constraints and changes in socio-cultural values, animal breeding must evolve toward a more sustainable model that guarantees production while promoting efficient resource use, animal health and welfare, and preserving genetic diversity. Thanks to recent developments in omics technologies, it is now possible to rethink breeding, taking advantage of improved knowledge on genome-to-phenome relationships that accounts for both genetic and non-genetic mechanisms controlling traits. GEroNIMO will work on chicken and pig, the most used sources of animal protein worldwide, to provide breeders with new knowledge and tools to promote innovative genome- and epigenome enabled selection methods for traits related to production (quantity and quality), efficiency, productive longevity, fertility, resilience and welfare. A large number of animals from cosmopolitan and local breeds will be characterized phenotypically, genetically and epigenetically under different environments to i) identify underlying biological mechanisms affecting trait variation, ii) develop methods to improve selection strategies integrating genetic- and non-genetic factors, and iii) propose strategies to optimize the conservation of genetic and epigenetic diversity. GEroNIMO proposes demand-driven innovation employing a multi-actor approach through the involvement of breeders, professional associations of animal production, and scientists, engaged from the planning phase to the dissemination of results over Europe. GEroNIMO will build on existing academic and commercial knowledge and will analyze large populations to quantify the contribution of genetic and epigenetic variation in gene expression, trait variation and trade-offs between traits. GEroNIMO will also propose a comprehensive and enhanced characterization of diversity by integrating epigenetic diversity into conservation purposes, corresponding to a new integrated conservation strategy.

Recent developments in genomics have advanced innovation in European aquaculture. However, despite the creation of reference quality genome sequences for the main species, our understanding of genome functions remains limited. AQUA-FAANG will deliver a step improvement in understanding of genome function and exploitation of genotype-to-phenotype prediction in the six most important European farmed fish species. The project brings together world-leading interdisciplinary expertise and industry partners providing direct pathways to commercial exploitation. AQUA-FAANG will functionally annotate the genomes of all six species, employing standardized experimental assays and analysis pipelines defined by the FAANG initiative. AQUA-FAANG datasets will be shared and coordinated with other FAANG initiatives via the FAANG data coordination centre, and made available through the Ensembl genome browser. As infectious disease is of paramount concern for sustainable aquaculture, the project focuses on understanding functional genomic regions in both healthy and immune-challenged fish. This will improve knowledge of the genomic basis for disease resistance and is complemented by novel approaches to increase understanding of immune cell heterogeneity. Standardized comparative analyses will provide essential insights into genome functions that cannot be gained from study of single species. Functional assays will be used to study intermediate phenotypes and prioritise causative genetic variants in trait-associated genomic regions to accelerate selection of disease-resistant stocks. Functionally-enriched marker panels will be developed to improve accuracy of genomic selection. An active programme of stakeholder engagement and dissemination will ensure uptake of project outputs by industry, academia, the public and in policy. The outputs will enhance precision breeding, drive competitiveness within the aquaculture sector, and enhance food and nutrition security in Europe.

CryoStore aims to create a lasting research and education network for a new generation of animal husbandry experts with a broad, multidisciplinary approach to the complexity of modern animal production and the conservation of farm animal biodiversity, taking into account economic, societal and environmental needs. A vibrant and effective animal breeding and production industry is essential to meet Europe´s increasing need for sustainable and secure food production. Farm animal and fish breeding are global, highly competitive and knowledge intensive sectors, and currently European breeding organisations are global leaders. If Europe is to maintain its competitive advantage in these strategically important industries innovative research is needed in those reproductive technologies that underpin efficient and profitable animal production. As such, CryoStore will develop innovative technologies for improved cryopreservation of germplasm (gametes, embryos, germ cells) for use in assisted reproductive procedures, leading to increased reproductive efficiency in Europe´s livestock and aquaculture industries. Technological advances in germplasm cryopreservation will also be of key importance to future initiatives aimed at conserving Europe’s livestock biodiversity, through genetic resource banking. Conserving Europe´s numerous and diverse native breeds, many of which are seriously threatened, will be of crucial importance to future sustainable animal production as genetic biodiversity allows the expression of advantageous traits influencing adaptability to harsh environments or disease resistance. It is likely that selecting for naturally occurring traits will help overcome future difficulties in livestock production wrought by climate change. The intensive training of CryoStore ESRs in a wide range of scientific and transferable skills will greatly enhance their future employability in Europe´s important animal production industries and conservation initiatives.

The vision of the EU aquaculture industry is to grow substantially in the next decade and to provide annually 4.5 million tons of sustainable food products. To this aim, NewTechAqua intends to expand and diversify EU production of finfish, molluscs and microalgae by developing and validating technologically-advanced, resilient and sustainable new solutions. The organizational approach of NewTechAqua is to group the solutions in 6 different categories: feed, Industry 4.0, sustainable farming, genetics, new species and new products. They will be validated on conventional (Atlantic salmon, rainbow trout, seabass and seabream) and emerging (greater amberjack, meagre, Senegalese sole and grey mullet) finfish species, molluscs (Pacific oyster, mussel) and microalgae. NewTechAqua is structured in 9 WPs. WP1 will conceive, formulate, produce and demonstrate three innovative sets of aquafeeds (pro-health, organic, zero waste). WP2 will establish new AI epidemiological models for enhancing the control of parasite outbreaks in Norwegian and Mediterranean farms. Sustainable aquaculture will be also promoted by advanced model systems and technologies for mollusc and in-land fish farms ecointensification. WP3 will develop innovative breeding programmes to improve performance, robustness and quality of farmed fish, molluscs and microalgae, while WP4 will achieve significant advances in reproduction technology of three emerging fish species. High-quality seafood products and sustainable food processing techniques for valorisation of by-products will be validated. WP6 will develop a set of indicators to monitor and measure progress towards the expected impacts, while market uptake of NewTechAqua results and outputs will be ensured by a detailed exploitation strategy (WP7). Finally, NewTechAqua will achieve well-targeted communication, dissemination and maximum transfer of generated know-how and project new technologies (WP8).