The LUMEN project is a groundbreaking initiative aimed at revolutionizing cross-domain collaboration and discovery processes in the fields of Mathematics (Maths), Social Sciences and Humanities (SSH), Earth System (ES), and Molecular Dynamics (MD), and beyond. Leveraging the successful GoTriple platform, renowned for its service to the SSH community, LUMEN seeks to extend its functionality to foster interoperability across scientific domains. Through interdisciplinary solutions spanning all four domains, LUMEN will redefine the process of discovery with radical innovations, simplifying initial research phases and facilitating access to advanced AI-powered tools for researchers. By expanding existing discovery platforms in the SSH and Maths domains and developing new platforms for other domains, LUMEN aims to fundamentally transform EOSC services, promoting innovative and customizable solutions for data discovery, attracting new users, and fostering Open Science principles. The project will also drive multidisciplinary cooperation through collaborative platforms and onboard new scientific communities into EOSC, providing them with the necessary tools. Ultimately, LUMEN seeks to revolutionize how research outputs are created, shared, and utilized across scientific domains, enhancing scientific discoveries, fostering interdisciplinary collaboration, and promoting innovation and trust in European scientific research.

High throughput sequencing and metagenomics have deepened our understanding of viruses in nature, yet linking viruses to their hosts remains a challenge, hindering our knowledge and applications. The VirHoX project aims to overcome this by "hacking" the ribosome to map virus-host associations. Leveraging a critical moment in the infection cycle of all viruses, the translation of viral genes into proteins by the host cell, we will uncover concealed relationships between viruses and their hosts, providing a universal tool for virus-host pairing. This novel approach, VirHo-seq, involves ligating host ribosomal RNA with viral mRNA during translation in infected cells using engineered enzymes, followed by high throughput sequencing to reveal virus-host pairings. Our interdisciplinary consortium of academic and industrial experts in microbiology, protein engineering, gene editing, viral genomics/transcriptomics and law, will develop and then prepare the commercialisation of VirHo-seq, envisioning legislative and analytical frameworks to maximise its impact. This technology will significantly help tackle current challenges, such as those posed by emerging pathogens, ecological disruptions, and climate change. Our approach aligns with the EIC Work Programme objectives, demonstrating feasibility on model organisms before validating on relevant samples, addressing the "engineered living materials" challenge.

FAIRCORE4EOSC focuses on the development and realisation of EOSC-Core components supporting a FAIR EOSC, addressing gaps identified in the SRIA. Leveraging existing technologies and services, the project will develop nine new EOSC-Core components aimed to improve the discoverability and interoperability of an increased amount of research outputs. FAIRCORE4EOSC will also contribute to the EOSC Interoperability Framework by establishing new guidelines on the new EOSC-Core components. The new components will be crucial to support the FAIR research life cycle. Five user-centric case studies (climate change, social sciences and humanities, mathematics, national research information systems, research data management communities) will drive the development and testing of the new components ensuring they are tailored to the user needs (co-design). All the selected case studies share similar challenges that are common to many other stakeholder groups: research communities at European and national level have datasets that currently cannot be found in the EOSC; they use Digital Object Identifiers (DOIs) but they are lacking PIDs for different levels of aggregation; they use community specific services to manage metadata that make cross-discipline reuse and interoperability complex. The user stories and best practices drawn by the case studies will be used to foster uptake of the new components beyond the project partners. The 22 complementary partners of the FAIRCORE4EOSC consortium have long-lasting experience in the provision and development of research data services, persistent identifiers, metadata and semantic registries, services and tools to archive and reference research software. The partners have also significantly contributed to the EOSC SRIA and are active members of the EOSC Association Task Forces (TFs) providing the project a unique insight and capacity to boost the development of the Web of FAIR Data and Related Services.