Gov4Nano will design and establish a well-positioned and broadly supported Nano Risk Governance Council (NRGC). Organizing, connecting and engaging are key activities in Gov4Nano and its creation of a sustainable NRGC. Gov4Nano will develop an operational trans disciplinary Nano Risk Governance Model (NRGM) for nanotechnologies, building on an established governance framework developed by the International Risk Governance Council (IRGC). Engaging stakeholders (including regulators) to proactively address nano-specific safety and seek dialogue for joint activities. NRGC and its precursor project Gov4Nano will engage, in order to support these activities, with the broad variety of stakeholders across all relevant nano-disciplines (chemical, biocides, food and feed, pharma and medical devices and materials development) and draft a review on our knowledge progress over the last decade whilst initiating dialog. To boost the quality of the dialog it will create a platform for dialogues between stakeholders in a “trusted environment” inclusive of civil society. The NRGC core business is to coordinate, guide and harmonize in order to overcome the fragmentation of current knowledge, information and needs over various sectors and disciplines (workers, consumers/patients, environmental safety) and to prepare the transfer of this knowledge. To that end, the NRGC will be equipped with a self-sustainable NanoSafety Governance Portal (NSGP) consolidating state-of-the-art and progressive nanosafety governance tools including ones for dialogues and measuring risk perception. Major efforts will be towards requirements for data harmonization and data curation to be defined and laid down in guidance on obtaining harmonized and standardized quality-scored data collections promoting a big data approach for nano-toxicology. Research activities will be initiated for regulatory sound knowledge in support of harmonized (OECD) guidance for characterization and testing of nanomaterials.

Aviation is one of the most critical infrastructures of the 21st century. Even comparably short interruptions can cause economic damage summing up to the Billion-Euro range. As evident from the past, aviation shows certain vulnerability with regard to natural hazards. The proposal EUNADICS-AV addresses airborne hazards (environmental emergency scenarios), including volcano eruptions, nuclear accidents and emergencies and other scenarios where aerosols and certain trace gases are injected into the atmosphere. Such events are considered rare, but may have an extremely high impact, as demonstrated during the European Volcanic Ash Crisis in 2010. Before the 1990s, insufficient monitoring as well as limited data analysis capabilities made it difficult to react to and to prepare for certain rare, high-impact events. Meanwhile, there are many data available during crisis situations, and the data analysis technology has improved significantly. However, there is still a significant gap in the Europe-wide availability of real time hazard measurement and monitoring information for airborne hazards describing “what, where, how much” in 3 dimensions, combined with a near-real-time European data analysis and assimilation system. The main objective of EUNADICS-AV is to close this gap in data and information availability, enabling all stakeholders in the aviation system to obtain fast, coherent and consistent information. This would allow a seamless response on a European scale, including ATM, ATC, airline flight dispatching and individual flight planning. In the SESAR 2020 Programme Execution Framework, EUNADICS-AV is a SESAR Enabling project (project delivering SESAR Technological Solutions). The project aims at passing a SESAR maturity level V2, which includes respective service validation activities, including validation exercises. Work will be also done to prepare a full V3 validation.

SAPHIR aims to develop vaccine strategies effective against endemic pathogens responsible for high economic losses in livestock in order to strengthen the profitability of food animal systems, improve animal welfare and reduce xenobiotic usage in farming with a One Health perspective. SAPHIR will bring novel vaccine strategies to the market i) at short term, with several promising vaccines brought to demonstration (RTL6), ii) at long term, with cutting edge strategies brought at proof of concept (RTL3) and iii) in line with socio-economic requirements. SAPHIR has selected two representative pathogens of pigs (Porcine Reproductive and Respiratory Syndrome Virus and Mycoplasma hyopneumoniae), chickens (Eimeria and Clostridium perfringens) and cattle (Bovine Respiratory Syncytial Virus, Mycoplasma bovis) to develop generic vaccine approaches applicable to other pathogens. SAPHIR will issue i) knowledge of immune mechanisms of protection, ii) affordable, safe and multivalent vaccines with DIVA properties, iii) efficient adjuvants targeting dendritic cells, optimal formulations, new mucosal and skin delivery systems, a new generation of DNA vectors and viral replicon platforms for fostering an earlier and longer duration of immunity including the perinatal period, and iv) basal biomarkers of individual immuno-competence for future breeding strategies. The SAPHIR dissemination and training programme includes creation of an integrated health management website, launch of a Global Alliance for Veterinary Vaccines and organization of workshops directed at food animal system stakeholders. This will ensure optimal research translation of SAPHIR outputs to market and field applications. SAPHIR brings together interdisciplinary expertise from fourteen academic institutes including a Chinese partner, five SMEs and two pharmaceutical companies.