BE READY NOW aims to implement the European Partnership for Pandemic Preparedness. This Partnership will gather 74 organisations from 24 countries, including public funding agencies, public health institutes, clinical networks, ministries and research infrastructures active in pandemic preparedness. This consortium is aligned around the vision of building a European research and innovation ecosystem optimally prepared for future health crises caused by infectious diseases, therefore contributing to the objectives of the European Research Area (ERA). To achieve its ambitious vision, BE READY NOW will align stakeholders in pandemic preparedness around shared research priorities to foster a coordinated and efficient research landscape, producing sustainable scientific, health, and socio-economic benefits. Through Joint Transnational Calls, BE READY NOW will help close critical research gaps covering the whole spectrum of pandemic preparedness research (including basic research, diagnostics, therapeutics, vaccines, and public health interventions), through an interdisciplinary approach. It will therefore directly address the goals of Horizon Europe’s Cluster 1 Health. Building on the infrastructures, projects and initiatives supported by the European Commission and Member States, BE READY NOW will establish and sustain an "ever-warm" research ecosystem, capable of pivoting swiftly in response to emerging health threats. This ecosystem will include an innovative, ever-warm EU-wide network of networks of clinical research sites. In the longer term, BE READY NOW will improve the EU's capacity in the areas of prevention, preparedness, surveillance, risk assessment and response to infectious diseases, ensuring the international visibility of the EU as a recognised actor for pandemic preparedness research and response, and providing resilience for citizens and health systems beyond the Partnership’s duration.