The high and growing global burden of cancer urges the need for effective implementation of primary cancer prevention (PCP) programmes targeting modifiable risk factors. However, evidence-based programmes with proven effectiveness under controlled environments often fail when implemented in the real world due to ineffective adaptation and implementation strategies addressing context-specific barriers, leading to programme failures and public health inequities. The PIECES project will develop, assess, and disseminate a cancer-specific methodological implementation framework, the integrated PCP Implementation Toolkit (PCP-IT). PCP-IT will provide an evidence-informed systematic process for (1) identification, selection, and tailoring of PCP programmes, and (2) developing evidence-informed implementation strategies tailored to local barriers and constraints. The PCP-IT will include a comprehensive repository of PCP programmes, their Theories of Change, and materials for systematically adapting the programmes to local needs and cultural constraints. The project involves 16 consortium members and implementation sites from 10 countries of diverse socio-cultural backgrounds and access to up to 77.7 million inhabitants. PIECES provides an ideal naturalistic laboratory to improve and study the up-scaling and implementation of a wide range of primary PCP programmes targeting major risk factors: tobacco, alcohol, low physical activity, HPV infection, sun exposure, and diet. A multi-site case comparison study will be conducted to assess and optimise implementation outcomes. An in-depth realist evaluation using various sociological theories will be conducted to explain the processes by which the outcomes are achieved. The consortium will employ a high-level external Advisory Board with renowned experts, facilitate continuous engagement with stakeholders, and align with the EU and relevant scientific societies to ensure the future continuity of both the repository and PCP-IT. This action is part of the Cancer Mission cluster of projects on ‘Prevention and early detection’.

The transport sector contributes to about 25% of total CO2 emissions in the EU and is the only sector where the trend is still increasing. Taking into account the growing demand on the road transport system and the ambitious targets of the EC’s Transport White Paper, it is paramount to increase the efficiency of freight transport. The vision of the AEROFLEX project is to support vehicle manufacturers and the logistics industry to achieve the coming challenges for road transport. The overall objective of the AEROFLEX project is to develop and demonstrate new technologies, concepts and architectures for complete vehicles with optimised aerodynamics, powertrains and safety systems as well as flexible and adaptable loading units with advanced interconnectedness contributing to the vision of a “physical internet”. The optimal matching of novel vehicle concepts and infrastructures is highly important, requiring the definition of smart infrastructure access policies for the next generation of trucks, load carriers and road infrastructure. The specific technical objectives, main innovations and targeted key results are: 1. Characterise the European freight transport market (map, quantify and predict), the drivers, the constraints, the trends, and the mode and vehicle choice criteria 2. Develop new concepts and technologies for trucks with reduced drag, which are safer, comfortable, configurable and cost effective and ensure satisfaction of intermodal customer needs under varying transport tasks and conditions. 3. Demonstrate potential truck aerodynamics and energy management improvements with associated impact assessments of the new vehicle concepts, technologies and features developed in the AEROFLEX project. 4. Drafting of coherent recommendations for revising standards and legislative frameworks in order to allow the new aerodynamic and flexible vehicle concepts on the road. To achieve an overall 18-33% efficiency improvement in road transport / long haulage by 2025+.