[Dataset] Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma
[Dataset] Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma
Adrenocortical carcinomas (ACCs) are invasive tumours arising in the adrenal cortex, and steroidogenic tumours are associated with worse prognostic outcomes. Loss-of-function mutations in sphingosine-1-phosphate lyase (SGPL1) cause primary adrenal insufficiency and as a key degradative enzyme in the sphingolipid pathway, SGPL1 also influences the balance of pro-proliferative and pro-apoptotic sphingolipids. We, therefore, hypothesized increased SGPL1 may be linked to increased disease severity in ACC.
We generated SGPL1 overexpressing H295R cells, as well as SGPL1 KO H295R cells and compared their transcriptomes by RNAseq. We used 3 biological replicates per group.
Peer reviewed
SGPL1, Sphingosine-1-phosphate lyase, http://metadata.un.org/sdg/3, Ensure healthy lives and promote well-being for all at all ages
SGPL1, Sphingosine-1-phosphate lyase, http://metadata.un.org/sdg/3, Ensure healthy lives and promote well-being for all at all ages
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