Lucía Méndez acknowledges the postdoctoral financial support received from AEI within the Juan de la Cierva Spanish Postdoctoral Program (IJC2020-046017-I/MCIN/AEI/10.13039/501100011033 and “NextGenerationEU”/PRTR”.) and Xunta de Galicia—Axencia Galega de Innovación (GAIN) (IN606C2021/003). The Spanish Ministry of Science and Innovation is also gratefully acknowledged for the doctoral fellowship to Silvia Muñoz. Bernat Miralles-Pérez acknowledges the postdoctoral financial support received from the Ministry of Universities and the Recovery, Transformation and Resilience Plan funded by the European Union–NextGenerationEU (2021URV-MS-15) and the doctoral financial support received from the Secretariat of Universities and Research of the Government of Catalonia, the European Union, and the European Social Fund (2018 FI_B 00919, 2019 FI_B1 00160, 2020 FI_B2 00119). The authors thank María Jesús González and Vanessa Sánchez-Martos for their excellent technical assistance. The authors gratefully acknowledge to AFAMSA (Vigo, Spain) and Taihua Shouyue (HK) International Co., Ltd. (Hong Kong, China) for generously provided the fish oil and the D-fagomine used in this study, respectively.

Obesity has been recognized as a major risk factor for chronic kidney disease, insulin resistance being an early common metabolic feature in patients suffering from this syndrome. This study aims to investigate the mechanism underlying the induction of kidney dysfunction and the concomitant onset of insulin resistance by long-term high-fat and sucrose diet feeding in Sprague Dawley rats. To achieve this goal, our study analyzed renal carbonylated protein patterns, ectopic lipid accumulation and fatty acid profiles and correlated them with biometrical and biochemical measurements and other body redox status parameters. Rats fed the obesogenic diet developed a prediabetic state and incipient kidney dysfunction manifested in increased plasma urea concentration and superior levels of renal fat deposition and protein carbonylation. An obesogenic diet increased renal fat by preferentially promoting the accumulation of saturated fat, arachidonic, and docosahexaenoic fatty acids while decreasing oleic acid. Renal lip

Peer reviewed