Cyclic AMP and Vfr increase the virulence of A. baumannii [Dataset]
Cyclic AMP and Vfr increase the virulence of A. baumannii [Dataset]
Virulence assay was performed three independent times using 30 G. mellonella larvae in total per A. baumannii strain or control (PBS). 48 h post-infection, 100% of the larvae in the control group survived. G. mellonella infected with wild-type (WT) AB5075 had survival rates of 40% while 63% and 77% of the larvae survived infection with ΔcavA mutant and vfr::Tn mutant respectively. Survival rates of larvae infected with the complemented ΔcavA+cavA and vfr::Tn+vfr strains were decreased to 40% and 27% respectively. Strains bearing empty miniTn7 vector (EV) were used as controls. In the interest of visual clarity, the X axis (Time) was set to start at 15 h. Data analysis with Log rank (Mantel-Cox) test indicated p<0.05 for the comparisons of WT vs ΔcavA and ΔcavA EV vs ΔcavA+cavA and p<0.01 for the comparisons of WT vs vfr::Tn and vfr:Tn EV vs vfr::Tn+vfr.
Peer reviewed
Virulence regulation, Baumannii &# 8217, Various aspects, Bacterial physiology, High potential target, Exopolysaccharide production, Central regulator, Throughput screening approach, Signalling cascade, Current treatment options, Resort antibiotics, Pathogenic success, Opportunistic nosocomial pathogen, Baumannii </, Cava ac, Established paradigm, Modulating quorum sensing, Vivo </, Leading position, Cyclic di, Using drna, Increasing resistance, Intrabacterial signalling, Ultimately governing virulence, Acinetobacter baumannii </, Inversely regulated, First time, Second messengers, Study uncovers, Ac ), cava, High morbidity, Directly proportional, Gmp systems, Cyclic amp, Adaptive antibiotic resistance, Mortality rates, Crucial mediator
Virulence regulation, Baumannii &# 8217, Various aspects, Bacterial physiology, High potential target, Exopolysaccharide production, Central regulator, Throughput screening approach, Signalling cascade, Current treatment options, Resort antibiotics, Pathogenic success, Opportunistic nosocomial pathogen, Baumannii </, Cava ac, Established paradigm, Modulating quorum sensing, Vivo </, Leading position, Cyclic di, Using drna, Increasing resistance, Intrabacterial signalling, Ultimately governing virulence, Acinetobacter baumannii </, Inversely regulated, First time, Second messengers, Study uncovers, Ac ), cava, High morbidity, Directly proportional, Gmp systems, Cyclic amp, Adaptive antibiotic resistance, Mortality rates, Crucial mediator
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