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Supplementary figure 1. Identified phenolic compounds in biscuits’ hydoalcoholic acid extracts (a), intestinal digests (b) and colonic fermented digests (c) expressed as a percentage of their content in biscuits with 17% of EBSG (b) (c) (a) . EBSG: Extruded brewers’ spent grain. Supplementary figure 2. IEC-6 viability for cookies’ digested extracts. * shows significant differences with positive control (C+) (p<0.05). D-TB: Traditional biscuit intestinal digest. D-FOS-EBSG0: Reduced sugar biscuit without extruded brewers spent grain intestinal digest. D-FOS-EBSG8: Reduced sugar biscuit with 8% extruded brewers spent grain intestinal digest. D-FOS-EBSG17: Reduced sugar biscuit with 17% extruded brewers spent grain intestinal digest. Supplementary figure 3. RAW 264.7 for cookies’ digested extracts. * shows significant differences with positive control (C+) (p<0.05). D-TB: Traditional biscuit intestinal digest. D-FOS-EBSG0: Reduced sugar biscuit without extruded brewers spent grain intestinal digest. D-FOS-EBSG8: Reduced sugar biscuit with 8% extruded brewers spent grain intestinal digest. D-FOS-EBSG17: Reduced sugar biscuit with 17% extruded brewers spent grain intestinal digest.
Table S1 –AGEs content for biscuits’ intestinal digests. Table S2–Biscuits’ extractable phenolic compounds profile. Table S3 – Biscuits intestinal and colonic fermented digests’ phenolic profile.
Supplementary data 1.
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