Document S1. Figures S1–S5. Table S1. RNA-seq quality and mapping data for B16 and CT26 cells, see STAR Methods - cDNA library preparation and illumina RNA sequencing. Table S2. Normalized read counts (FPKM) for each gene in each RNA-seq assay, see STAR Methods - Gene expression quantitation and differential expression analysis. Table S3. List of 50 top upregulated genes in B16 resistant clones relative to treatment-naïve cells, related to Figure 4A. Table S4. List of 50 top downregulated genes in B16 resistant clones relative to treatment-naïve cells, related to Figure 4A. Table S5. List of the top 500 upregulated genes in B16 resistant clones (relative to naïve B16 cells) and their corresponding log2 fold change in CT26 C1 and C4 clones (relative to naïve CT26 cells), related to Figure 7E. NA: not applicable.

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