Supplementary Figure 1. Related to Figure 1. Characterization of the cholinergic system in bone. Supplementary Figure 2. Related to Figure 2. Interleukin-6 induces a cholinergic switch in sympathetic neurons. Supplementary Figure 3. Related to Figures 2 and 3. Interleukin-6 induces a cholinergic switch of sympathetic fibers in bone. Supplementary Figure 4. Related to Figure 4. Osteolineage cells contribute to the non-neuronal cholinergic system. Supplementary Figure 5. Related to Figure 5. GFRa2 loss causes reduced bone thickness and osteocyte degeneration. Supplementary Figure 6. Related to Figure 6. GFRa2 signaling maintains osteocyte connectivity and survival. Supplementary Figure 7. Related to Figure 7. Moderate exercise increases bone cholinergic innervation through sympathetic cholinergic fibers. Table S1. Oligonucleotide sequences used for mouse genotyping. Table S2. Oligonucleotide sequences used for quantitative real-time RT-PCR.

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