Dataset related to article: Human macrophages stimulate expression of inflammatory mediators in adipocytes; effects of second-generation antipsychotics and glucocorticoids on cellular cross-talk

Research datakeyboard_double_arrow_right Dataset 01 Jan 2021Embargo end date: 07 Jul 2021 Spain English Publisher:Digital.CSICFunded by:EC | TREATMENT

Authors: Sarsenbayeva, Assel; Dipta, Priya; Lundqvist, Martin; Almby, Kristina E.; Tirosh, Boaz; Nunzio, Giada Di; Eriksson, Jan W.; +1 Authors

doi: 10.20350/digitalcsic/13924

handle: 10261/245376

Dataset related to article: Human macrophages stimulate expression of inflammatory mediators in adipocytes; effects of second-generation antipsychotics and glucocorticoids on cellular cross-talk

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Abstract

Direct effects of SGAs on macrophage-adipocyte communication. The xls file shows the raw data obtained from the measurement of gene expression from the isolated human mature adipocytes co-cultured with THP-1 derived macrophages pre-treated with ARI, OLA, and dehydroaripiprazole (dARI) and gene expression in macrophages treated with ARI, OLA and dARI during and after their polarisation.

Macrophages induce expression of pro-inflammatory genes in human subcutaneous adipocytes without affecting the expression of adipokines or genes involved in energy regulation SGAs and dexamethasone had a mild effect on macrophage-adipocyte communication in M1 macrophage phenotype

European Comission ITN Treatment H2020-MSCA-ITN-721236

Peer reviewed

Country

Spain

Related Organizations

Spanish National Research Council
Spain

Keywords

Inflammation, Second Generationantipsychotics, Glucorticoids, Macrophages, Adipose tissue

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