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BindingDB Entry 50033062: Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery.

Authors: BindingDB;

BindingDB Entry 50033062: Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery.

Abstract

Small molecule binding data for protein 3-phosphoinositide dependent protein kinase-1, AKT/p21CIP1, Apoptosis Signal-regulating Kinase 1 (ASK1), Aurora kinase B/Inner centromere protein, Cyclin-dependent kinase 2, Inhibitor of NF-kappa-B kinase (IKK), Insulin receptor, Insulin-like growth factor I receptor, JAK3/JAK1, PI3-kinase subunit alpha, Ribosomal protein S6 kinase (P70S6K), Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Sgk1, Tyrosine-protein kinase SYK, Vascular endothelial growth factor receptor 2, and c-Jun N-terminal kinase, JNK, Uniprot O00141, O14757, O14965, O15111, O15530, P06213, P08069, P23443, P24941, P31749, P35968, P42336, P43405, P45983, P52333, Q96GD4, and Q99683

Keywords

3-phosphoinositide dependent protein kinase-1, AKT/p21CIP1, Apoptosis Signal-regulating Kinase 1 (ASK1), Aurora kinase B/Inner centromere protein, Cyclin-dependent kinase 2, Inhibitor of NF-kappa-B kinase (IKK), Insulin receptor, Insulin-like growth factor I receptor, JAK3/JAK1, PI3-kinase subunit alpha, Ribosomal protein S6 kinase (P70S6K), Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Sgk1, Tyrosine-protein kinase SYK, Vascular endothelial growth factor receptor 2, and c-Jun N-terminal kinase, JNK, Affinity

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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