Raw read counts and phased SNP counts for every single cell in the sequencing datasets of the breast cancer patient S1 from "Characterizing allele- and haplotype-specific copy numbers in single cells with CHISEL"

Research datakeyboard_double_arrow_right Dataset 08 May 2020Publisher:ZenodoFunded by:NSF | CAREER: Algorithms for Ne..., NIH | Pathway and Network Integ..., NIH | Computational Characteriz...

Authors: Zaccaria, Simone; Raphael, Benjamin J.;

doi: 10.5281/zenodo.3817536 , 10.5281/zenodo.3817535

Raw read counts and phased SNP counts for every single cell in the sequencing datasets of the breast cancer patient S1 from "Characterizing allele- and haplotype-specific copy numbers in single cells with CHISEL"

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Abstract

This dataset contains the raw read counts and phased SNP counts for every single cell in the sequencing datasets of breast cancer patient S1 from “Characterizing allele- and haplotype-specific copy numbers in single cells with CHISEL” [Zaccaria & Raphael, 2020]. These data enable the full reproduction of all the results in the related manuscript for breast cancer patient S1. Specifically, the data are provided in two files for every dataset DAT of patient S1 with the following format: DAT.raw_read_counts.bed.gz is a multi-cell BED file containing the raw read counts in the following fields: CHROMOSOME: the name of a human chromosome START: the starting genomic position of a genomic bin in the chromosome END: the ending genomic position of the genomic bin in the chromosome CELL: the cell barcode that uniquely identifies a cell NORMAL: the raw read count for the specified bin from a matched-normal sample COUNT: the raw read count for the specified bin in the specified cell RDR: the estimated read-depth ratio for the specified bin in the specified cell DAT.phased_snps_counts.pos.gz is a multi-cell POS file containing the phased SNP counts in the following fields: CHROMOSOME: the name of a human chromosome POS: the genomic position in the chromosome of a germline SNP CELL: the cell barcode that uniquely identifies a cell COUNT_HAPLOTYPE_A: the count of reads that cover the SNP and that belong to haplotype A in the specified cell COUNT_HAPLOTYPE_B: the count of reads that cover the SNP and that belong to haplotype B in the specified cell All the files have been compressed using standard gzip.

Related Organizations

College of New Jersey
United States

Keywords

copy-number, cancer, DNA sequencing, single-cell

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