Hematopoietic stem cells' conditioned media dysregulate mitochondrial dynamics in colorectal cancer cell through Drp-1-mediated excessive mitochondrial fission
Hematopoietic stem cells' conditioned media dysregulate mitochondrial dynamics in colorectal cancer cell through Drp-1-mediated excessive mitochondrial fission
Hematopoietic stem cell-derived conditioned media (HSC-CM) compromises the mitochondrial dynamics by inducing excessive mitochondrial fission in colorectal cancer (CRC) cells. This occurs via upregulation of DRP-1 and it’s complex protein. The excessive fission leads to severe mitochondrial dysfunction, characterized by a loss of mitochondrial membrane potential (MMP) and impaired bioenergetics, including decreased ATP production and disrupted electron transport chain (ETC) complexes. This energy crisis and overproduction of reactive oxygen species (ROS) ultimately trigger intrinsic apoptosis and mitophagy, leading to the clearance of CRC cells.
Data Set Description 116: HCT-116_Control 116_t: HCT-116_CMTreated
mitochondrial dynamics, fission, hematopoietic stem cells, mitophagy, Drp-1
mitochondrial dynamics, fission, hematopoietic stem cells, mitophagy, Drp-1
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